Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) antibody

Details for Product No. ABIN152873
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Antigen
Synonyms CG12019, CPDR-1, CPDR-2, DROCPDR, Dmel\\CG12019, E(sev)3B, cdc37, Afu4g10010, P50CDC37, p50, p50Cdc37
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(86), (41), (38), (12), (12), (12), (1), (1), (1)
Host
Mouse
(83), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)
(78), (36), (26), (25), (21), (15), (10), (9), (8)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN152873
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Immunogen Purified mouse Cdc 37 fusion protein.
Clone C1
Isotype IgG2b
Specificity Cdc37 (C1)
Cross-Reactivity (Details) Not yet tested in other species.
Purification Ascites
Alternative Name CDC37
Background In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell divisioncycle through its action on cyclin-dependent kinases (CDK',s). Cdc37 has alsobeen associated with signaling pathways and kinases unrelated to cell cycle control,including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosinekinase. Interestingly, HSP90 has also been shown to be associated with many of thesame cellular targets as Cdc37.It has now been shown that Cdc37 is the same protein previously described as p50which has been found to be associated with many of the same proteins as HSP90.Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn,Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown tobe a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessaryfor the binding of HSP90 to Cdk4. Alternate Names: anti-S cerevisiae hypothetical protein CDC37 antibody, anti-CDC 37 antibody,anti-CDC37 antibody, anti-CDC37 cell division cycle 37 homolog antibody, anti-Cdc37homolog antibody, anti-CDC37 protein antibody, anti-Cell division cycle 37 homologantibody, anti-Hsp90 chaperone protein kinase targeting subunit antibody, anti-Hsp90chaperone protein kinase targeting subunit p50Cdc37 antibody, anti-Hsp90 cochaperone Cdc37 antibody, anti-p50 antibody, anti-p50Cdc37 antibody.
Gene Symbol: CDC37
Gene ID 11140, 12539, 114562
Research Area Cell Cycle, CD Antigens, Surface Receptors of Immune Cells
Application Notes Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody recognizes a single 50 kDa protein representing Cdc 37 in HeLa cell extract. Immunofluorescence staining of Cdc 37 in Hepa1 cells results in mostly cytoplasmic staining concentrated around the nuclear membrane.
Recommended dilutions: Immunoprecipitation 1:10-1:500, Western Blot 1:5, Immunocytochemistry/Immunofluorescence 1:200, Immunohistochemistry-Paraffin, Immunohistochemistry 1:10-1:2000
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Aliquot and store at -20 °C or -80 °C.
General Perdew, Wiegand, Vanden Heuvel et al.: "A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37." in: Biochemistry, Vol. 36, Issue 12, pp. 3600-7, 1997 (PubMed).

Lamphere, Fiore, Xu et al.: "Interaction between Cdc37 and Cdk4 in human cells." in: Oncogene, Vol. 14, Issue 16, pp. 1999-2004, 1997 (PubMed).

Kimura, Rutherford, Miyata et al.: "Cdc37 is a molecular chaperone with specific functions in signal transduction." in: Genes & development, Vol. 11, Issue 14, pp. 1775-85, 1997 (PubMed).

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