Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) antibody

Details for Product No. ABIN152873
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Antigen
Synonyms P50CDC37, CG12019, CPDR-1, CPDR-2, DROCPDR, Dmel\\CG12019, E(sev)3B, cdc37, Afu4g10010
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(55), (36), (35), (12), (12), (12), (1)
Host
Mouse
(51), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(46), (25), (20), (20), (11), (10), (6), (4), (3)
Pubmed 3 references available
Catalog no. ABIN152873
Quantity 0.1 mL
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Immunogen Purified mouse Cdc 37 fusion protein.
Clone C1
Isotype IgG2b
Specificity Species Reactivity: Cross-reacts with Human, Rat, Mouse and Hamster.Not yet tested in other species. Localization: Cytoplasmic and Nuclear.
Cross-Reactivity Hamster, Human, Mouse (Murine), Rat (Rattus)
Purification Ascites
Alternative Name CDC37
Background In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell divisioncycle through its action on cyclin-dependent kinases (CDK',s). Cdc37 has alsobeen associated with signaling pathways and kinases unrelated to cell cycle control,including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosinekinase. Interestingly, HSP90 has also been shown to be associated with many of thesame cellular targets as Cdc37.It has now been shown that Cdc37 is the same protein previously described as p50which has been found to be associated with many of the same proteins as HSP90.Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn,Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown tobe a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessaryfor the binding of HSP90 to Cdk4. Alternate Names: anti-S cerevisiae hypothetical protein CDC37 antibody, anti-CDC 37 antibody,anti-CDC37 antibody, anti-CDC37 cell division cycle 37 homolog antibody, anti-Cdc37homolog antibody, anti-CDC37 protein antibody, anti-Cell division cycle 37 homologantibody, anti-Hsp90 chaperone protein kinase targeting subunit antibody, anti-Hsp90chaperone protein kinase targeting subunit p50Cdc37 antibody, anti-Hsp90 cochaperone Cdc37 antibody, anti-p50 antibody, anti-p50Cdc37 antibody.
Gene ID 11140, 12539, 114562
Research Area Cell Cycle, CD Antigens, Surface Receptors of Immune Cells
Application Notes Suggested working dilutions: Western Blot 1:5,000,Immunocytochemistry 1:200
Restrictions For Research Use only
Format Liquid
Buffer Preservative: 0.05% sodium azide
Preservative Sodium azide
Storage -20 °C
General Perdew, Wiegand, Vanden Heuvel et al.: "A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37." in: Biochemistry, Vol. 36, Issue 12, pp. 3600-7, 1997 (PubMed).

Lamphere, Fiore, Xu et al.: "Interaction between Cdc37 and Cdk4 in human cells." in: Oncogene, Vol. 14, Issue 16, pp. 1999-2004, 1997 (PubMed).

Kimura, Rutherford, Miyata et al.: "Cdc37 is a molecular chaperone with specific functions in signal transduction." in: Genes & development, Vol. 11, Issue 14, pp. 1775-85, 1997 (PubMed).

Hosts (51), (4)
Reactivities (55), (36), (35), (12), (12), (12), (1)
Applications (46), (25), (20), (20), (11), (10), (6), (4), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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