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Details for Product No. ABIN152880

Scavenger Receptor Class B, Member 1 (SCARB1) antibody

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Antigen
Synonyms CD36L1, CLA-1, CLA1, HDLQTL6, SR-BI, SRB1, AI120173, CD36, Cd36l1, Cla-1, Cla1, D5Ertd460e, Hdlq1, Hlb398, SR-B1, SRBI, Srb1, mSR-BI, cb1015, SCARB1, Scarb1
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus), Mustelid
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 13 references available
Catalog no. ABIN152880
Quantity 0.1 mL
Price
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Immunogen A peptide containing residues 496-509 from mouse SR-BI plus an N-terminal cysteinewas coupled to KLH. CSPAAKGTVLQEAKL-COOH.
Specificity ABIN152880 is specific for SR-BI. Species Reactivity: Reacts with mouse, rat human, and hamster SR-BI. Localization: Cell Membrane, multi-pass membrane protein.
Cross-Reactivity Hamster, Rat (Rattus)
Purification Serum
Alternative Name SCARB1
Background High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and theirplasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BIbinds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDLwith high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues,and mediates selective cholesterol uptake by a distinct mechanism.In mice, it seems that SR-BI plays a key role in determining the levels of plasmalipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Alternate Names: anti-SCARB1 antibody, anti-SR-B1 antibody, anti-SR-BI antibody, anti-ScavengerReceptor-BI antibody, anti-Scavenger Receptor-B1 antibody, anti-HCLA 1 antibody,anti-SRBI antibody, anti-SR BI antibody, anti-SRB1 antibody, anti-CD36 and LIMPIIanalogous 1 antibody, anti-CD36 antigen antibody, anti-CD36L1 antibody, anti-CLA1antibody, anti-CLA 1 antibody, anti-Collagen type I receptor, anti-thrombospondinreceptor-like 1 antibody, anti-Scavenger Receptor Class B Type 1 antibody,anti-scavenger receptor class B type 1 antibody, anti-scavenger receptor class B type IIIantibody, anti-scavenger receptor class B, member 1 antibody, anti-MGC138242antibody. Related Diseases: Cancer, Coronary Artery Disease, Atherosclerosis
Gene ID 949, 20778, 25073
UniProt Q61009
Application Notes immunoprecipitation 4-8 ug/ml lysate,Western Blot 1:1000. Positive Controls: mouse liver lysate
Restrictions For Research Use only
Format Liquid
Buffer n/a
Storage -20 °C
Frolov, Petrescu, Atshaves et al.: "High density lipoprotein-mediated cholesterol uptake and targeting to lipid droplets in intact L-cell fibroblasts. A single- and multiphoton fluorescence approach." in: The Journal of biological chemistry, Vol. 275, Issue 17, pp. 12769-80, 2000 (PubMed).

Wang, Silver, Costet et al.: "Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 33053-8, 2000 (PubMed).

Husemann, Loike, Kodama et al.: "Scavenger receptor class B type I (SR-BI) mediates adhesion of neonatal murine microglia to fibrillar beta-amyloid." in: Journal of neuroimmunology, Vol. 114, Issue 1-2, pp. 142-50, 2001 (PubMed).

Han, Nicholson, Zhou et al.: "Oxidized low density lipoprotein decreases macrophage expression of scavenger receptor B-I." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16567-72, 2001 (PubMed).

Ohgami, Nagai, Miyazaki et al.: "Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products." in: The Journal of biological chemistry, Vol. 276, Issue 16, pp. 13348-55, 2001 (PubMed).

Silver, Wang, Xiao et al.: "High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion." in: The Journal of biological chemistry, Vol. 276, Issue 27, pp. 25287-93, 2001 (PubMed).

Cai, Kirby, Howles et al.: "Differentiation-dependent expression and localization of the class B type I scavenger receptor in intestine." in: Journal of lipid research, Vol. 42, Issue 6, pp. 902-9, 2001 (PubMed).

Tsuruoka, Khovidhunkit, Brown et al.: "Scavenger receptor class B type I is expressed in cultured keratinocytes and epidermis. Regulation in response to changes in cholesterol homeostasis and barrier requirements." in: The Journal of biological chemistry, Vol. 277, Issue 4, pp. 2916-22, 2002 (PubMed).

Huang, Mazzone: "ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression." in: Journal of lipid research, Vol. 43, Issue 3, pp. 375-82, 2002 (PubMed).

Silver: "A carboxyl-terminal PDZ-interacting domain of scavenger receptor B, type I is essential for cell surface expression in liver." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34042-7, 2002 (PubMed).

Willner, Tow, Buhman et al.: "Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 3, pp. 1262-7, 2003 (PubMed).

Basso, Freeman, Knapper et al.: "Role of the hepatic ABCA1 transporter in modulating intrahepatic cholesterol and plasma HDL cholesterol concentrations." in: Journal of lipid research, Vol. 44, Issue 2, pp. 296-302, 2003 (PubMed).

Zhang, Ahmed, McFarlane et al.: "Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways." in: Journal of lipid research, Vol. 48, Issue 2, pp. 405-16, 2007 (PubMed).

Alternatives for antigen "Scavenger Receptor Class B, Member 1 (SCARB1)", type "Antibodies"
Hosts (62), (13), (5)
Reactivities (56), (53), (45), (17), (17), (17), (7), (4), (2), (2)
Applications (58), (25), (23), (19), (17), (17), (15), (10), (10), (7), (5), (2), (2), (1)
Conjugates (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (12), (5), (3), (2), (1)
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