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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Scavenger Receptor Class B, Member 2 (SCARB2) antibody
|Synonyms||AMRF, CD36L2, HLGP85, LIMPII, SR-BII, LGP85, Cd36l2, LIMP-2, MLGP85, 9330185J12Rik, LimpII, cd36l2, fi13c07, chunp6914, wu:fi13c07, SCARB2, scarb2, MGC140207|
Alternatives Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|8 references available|
|Quantity||0.1 ml (Variants)|
|Price||Product not available in this region.|
|Gene ID||950, 12492, 117106|
|Immunogen||A peptide containing residues from mouse SR-BII (2).|
|Cross-Reactivity||Cow (Bovine), Hamster, Rat (Rattus)|
|Description||High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and theirplasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI andSR-BII (previously known as SR-BI.2) are the alternatively spliced products of a singlegene. SR-BII differs from SR-BI in that the encoded c-terminal cytoplasmic domain isalmost completely different. SR-BII binds HDLs and mediates selective uptake of HDLcholesteryl ester, but with an approximately 4-fold lower efficiency than SR-BI. Nuclease protection assays show SR-BII to be abundant in mouse tissues expressingSR-BI, with SR-BII expression found in liver, adrenal glands, and testes.Although the role of SR-BII is not completely clear, research suggests that it may be afunctional HDL receptor. In addition, SR-BII mRNA results from the alternative splicingof SR-BI precursor transcripts with the SR-BII isoform mediating selective transfer oflipid between HDL and cells. The relative expression and functional activities of thesetwo isoforms create a potential means of regulating selective lipid transfer between HDLand cells. (1-6). Alternate Names: anti-SR-B2 antibody, anti-SR-BII antibody, anti-Scavenger Receptor-BII antibody,anti-Scavenger Receptor-B2 antibody. Related Diseases: Cancer|
|Specificity||400-102 is specific for the SR-BII. Species Reactivity: Mouse, rat, bovine, human, mink and hamster SR-BII.|
|Application Notes||Suggested working dilutions: immunofluorescence 1:500- 1:1000,Western Blot 1:1000,Immunohistochemistry-Paraffin 1:25|
|Buffer||serum. Preservative: 0.1% sodium azide.|
|Storage||Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.|
|Restrictions||For Research Use only|
|Detection of SR-BII in Jurkat whole cell lysate using ABIN152881. Lane 1: 1:1000 Lane 2: 1:500 Lane 3: 1:100|
Rigotti, Trigatti, Penman et al.: "A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 23, pp. 12610-5, 1997 (PubMed).
Krieger: "The "best" of cholesterols, the "worst" of cholesterols: a tale of two receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 8, pp. 4077-80, 1998 (PubMed).
Wadsack, Hirschmugl, Hammer et al.: "Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins." in: The international journal of biochemistry & cell biology, Vol. 35, Issue 4, pp. 441-54, 2003 (PubMed).
Kocher, Yesilaltay, Cirovic et al.: "Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism." in: The Journal of biological chemistry, Vol. 278, Issue 52, pp. 52820-5, 2003 (PubMed).
Akpovi, Yoon, Vitale et al.: "The predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis." in: Journal of lipid research, Vol. 47, Issue 10, pp. 2233-47, 2006 (PubMed).
Huby, Doucet, Dachet et al.: "Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues." in: The Journal of clinical investigation, Vol. 116, Issue 10, pp. 2767-76, 2006 (PubMed).
Zhang, Moor, Merkler et al.: "Regulation of alternative splicing of liver scavenger receptor class B gene by estrogen and the involved regulatory splicing factors." in: Endocrinology, Vol. 148, Issue 11, pp. 5295-304, 2007 (PubMed).
Barth, Schnober, Neumann-Haefelin et al.: "Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells." in: Journal of virology, Vol. 82, Issue 7, pp. 3466-79, 2008 (PubMed).
|Hosts||Rabbit (14), Goat (3), Mouse (1)|
|Reactivities||Human (15), Mouse (Murine) (11), Rat (Rattus) (5), Cow (Bovine) (1), Dog (Canine) (1), Hamster (1), Mink (1)|
|Applications||Western Blotting (WB) (16), ELISA (10), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunohistochemistry (IHC) (4), Immunocytochemistry (ICC) (2), Immunofluorescence (IF) (2), Immunoprecipitation (IP) (2)|
|Epitopes||C-Term (3), AA 491-506 (1), Internal Region (1), Middle Region (1), N-Term (1)|