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|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Scavenger Receptor Class B, Member 1 (SCARB1) antibody
|Synonyms||CLA1, SRB1, CLA-1, SR-BI, CD36L1, MGC138242, CD36, Cla1, SRBI, Srb1, Cla-1, SR-B1, Cd36l1, mSR-BI, AI120173, D5Ertd460e, SCARB1, cb1015, Scarb1|
Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
|26 references available|
|Quantity||0.1 ml (3.0 mg/ml) (Variants)|
|Price||Product not available in this region.|
|Gene ID||949, 20778, 25073|
|Immunogen||A C-terminal peptide containing residues from mouse Scavenger Receptor-BI (withinresidues 450-509).|
|Cross-Reactivity||Human, Mouse (Murine), Rat (Rattus)|
|Description||High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and theirplasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BIbinds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDLwith high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues,and mediates selective cholesterol uptake by a distinct mechanism.In mice, it seems that SR-BI plays a key role in determining the levels of plasmalipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland. Alternate Names: anti-SCARB1 antibody, anti-SR-B1 antibody, anti-SR-BI antibody, anti-ScavengerReceptor-BI antibody, anti-Scavenger Receptor-B1 antibody, anti-HCLA 1 antibody,anti-SRBI antibody, anti-SR BI antibody, anti-SRB1 antibody, anti-CD36 and LIMPIIanalogous 1 antibody, anti-CD36 antigen antibody, anti-CD36L1 antibody, anti-CLA1antibody, anti-CLA 1 antibody, anti-Collagen type I receptor, anti-thrombospondinreceptor-like 1 antibody, anti-Scavenger Receptor Class B Type 1 antibody,anti-scavenger receptor class B type 1 antibody, anti-scavenger receptor class B type IIIantibody, anti-scavenger receptor class B, member 1 antibody, anti-MGC138242antibody.|
|Specificity||400-104 is specific for the SR-BI. Species Reactivity: Reacts with mouse, rat, mink and hamster SR-BI and the long form of human CLA-I.|
|Application Notes||Suggested working dilutions: Western Blot 1:1000 -1:5000|
|Buffer||Tris-citrate/phosphate [pH 7-8] buffer.|
|Storage||Store at 4C. Do not freeze.|
|Restrictions||For Research Use only|
Witt, Kolleck, Fechner et al.: "Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells." in: Journal of lipid research, Vol. 41, Issue 12, pp. 2009-16, 2001 (PubMed).
Hullinger, Panek, Xu et al.: "p21-activated kinase-1 (PAK1) inhibition of the human scavenger receptor class B, type I promoter in macrophages is independent of PAK1 kinase activity, but requires the GTPase-binding domain." in: The Journal of biological chemistry, Vol. 276, Issue 50, pp. 46807-14, 2001 (PubMed).
Han, Parsons, Zhou et al.: "Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104)." in: Circulation, Vol. 110, Issue 22, pp. 3472-9, 2004 (PubMed).
Brodeur, Luangrath, Bourret et al.: "Physiological importance of SR-BI in the in vivo metabolism of human HDL and LDL in male and female mice." in: Journal of lipid research, Vol. 46, Issue 4, pp. 687-96, 2005 (PubMed).
Lemieux, Guelinas, Lalonde et al.: "Hypolipidemic action of the SERM acolbifene is associated with decreased liver MTP and increased SR-BI and LDL receptors." in: Journal of lipid research, Vol. 46, Issue 6, pp. 1285-94, 2005 (PubMed).
Lalanne, Lambert, Amar et al.: "Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells." in: Journal of lipid research, Vol. 46, Issue 6, pp. 1312-9, 2005 (PubMed).
Johansson, Rudling, Scanlan et al.: "Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 29, pp. 10297-302, 2005 (PubMed).
Harder, Vassiliou, McBride et al.: "Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy." in: Journal of lipid research, Vol. 47, Issue 3, pp. 492-503, 2006 (PubMed).
Yesilaltay, Morales, Amigo et al.: "Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility." in: Endocrinology, Vol. 147, Issue 4, pp. 1577-88, 2006 (PubMed).
Thomuas-Moyua, Gianotti, Proenza et al.: "The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats." in: Journal of lipid research, Vol. 47, Issue 9, pp. 2042-8, 2006 (PubMed).
Sanue, Sinnett, Delvin et al.: "Localization and role of NPC1L1 in cholesterol absorption in human intestine." in: Journal of lipid research, Vol. 47, Issue 10, pp. 2112-20, 2006 (PubMed).
Akpovi, Yoon, Vitale et al.: "The predominance of one of the SR-BI isoforms is associated with increased esterified cholesterol levels not apoptosis in mink testis." in: Journal of lipid research, Vol. 47, Issue 10, pp. 2233-47, 2006 (PubMed).
Azhar, Medicherla, Shen et al.: "LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells." in: Journal of lipid research, Vol. 47, Issue 11, pp. 2538-50, 2006 (PubMed).
Zhong, Gastaminza, Chung et al.: "Persistent hepatitis C virus infection in vitro: coevolution of virus and host." in: Journal of virology, Vol. 80, Issue 22, pp. 11082-93, 2006 (PubMed).
Wadsack, Tabano, Maier et al.: "Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition." in: American journal of physiology. Endocrinology and metabolism, Vol. 292, Issue 2, pp. E476-84, 2007 (PubMed).
Timmers, Sharma, Opavsky et al.: "E2f1, E2f2, and E2f3 control E2F target expression and cellular proliferation via a p53-dependent negative feedback loop." in: Molecular and cellular biology, Vol. 27, Issue 1, pp. 65-78, 2006 (PubMed).
Qu, Perdomo, Su et al.: "Effects of apoA-V on HDL and VLDL metabolism in APOC3 transgenic mice." in: Journal of lipid research, Vol. 48, Issue 7, pp. 1476-87, 2007 (PubMed).
During, Harrison: "Mechanisms of provitamin A (carotenoid) and vitamin A (retinol) transport into and out of intestinal Caco-2 cells." in: Journal of lipid research, Vol. 48, Issue 10, pp. 2283-94, 2007 (PubMed).
Yvan-Charvet, Pagler, Wang et al.: "SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL." in: Journal of lipid research, Vol. 49, Issue 1, pp. 107-14, 2007 (PubMed).
Valiyaveettil, Kar, Ashraf et al.: "Oxidized high-density lipoprotein inhibits platelet activation and aggregation via scavenger receptor BI." in: Blood, Vol. 111, Issue 4, pp. 1962-71, 2008 (PubMed).
Eacker, Agrawal, Qian et al.: "Hormonal regulation of testicular steroid and cholesterol homeostasis." in: Molecular endocrinology (Baltimore, Md.), Vol. 22, Issue 3, pp. 623-35, 2008 (PubMed).
Tietge, Nijstad, Havinga et al.: "Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion." in: Journal of lipid research, Vol. 49, Issue 3, pp. 563-71, 2008 (PubMed).
Barth, Schnober, Neumann-Haefelin et al.: "Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells." in: Journal of virology, Vol. 82, Issue 7, pp. 3466-79, 2008 (PubMed).
Montoudis, Seidman, Boudreau et al.: "Intestinal fatty acid binding protein regulates mitochondrion beta-oxidation and cholesterol uptake." in: Journal of lipid research, Vol. 49, Issue 5, pp. 961-72, 2008 (PubMed).
Ashraf, Kar, Chen et al.: "Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters." in: The Journal of biological chemistry, Vol. 283, Issue 16, pp. 10408-14, 2008 (PubMed).
Drover, Nguyen, Bastie et al.: "CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice." in: The Journal of biological chemistry, Vol. 283, Issue 19, pp. 13108-15, 2008 (PubMed).
|Hosts||Rabbit (16), Mouse (4), Goat (1)|
|Reactivities||Rat (Rattus) (12), Human (11), Mouse (Murine) (11), Hamster (2), Mink (2)|
|Applications||Western Blotting (WB) (14), ELISA (7), Immunohistochemistry (IHC) (6), Flow Cytometry (FACS) (3), Immunoprecipitation (IP) (3), Functional Studies (Func) (2), Immunocytochemistry (ICC) (2), Immunofluorescence (IF) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (2), Neutralization (Neut) (2)|
|Epitopes||N-Term (5), AA 144-163 (1)|