ATP-Binding Cassette, Sub-Family G (WHITE), Member 8 (ABCG8) antibody

Antigen: ATP-Binding Cassette, Sub-Family G (WHITE), Member 8 (ABCG8)

Synonyms: GBD4, STSL, MGC142217, AI114946, sterolin-2, 1300003C16Rik, ABCG8, zgc:172358

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN152894

Additional Information

Alternative name: ABCG8

Gene ID: 64241, 67470

UniProt: Q9H221

Immunogen: A synthetic peptide from the n-terminal region of human ABCG8 protein.

Cross-Reactivity: Human, Mouse (Murine)

Description: ATP-binding cassette (ABC) transporter genes are involved in the regulation of theamount of dietary cholesterol retained in the body. ABCG8, expressed at high levels inthe liver and intestine, normally cooperates with ABCG5 to limit intestinal absorption andpromote biliary excretion of sterols. The mutated form of this transporter can lead tosterol accumulation and atherosclerosis or sitosterolemia, a rare autosomal recessivedisorder, characterized by hyperabsorption of sterols and the inability to excrete sterolsinto bile. Alternate Names: anti-ATP binding cassette sub family G (WHITE) member 8 (sterolin 2) antibody,anti-ATP binding cassette sub family G member 8 antibody, anti-MGC142217 antibody,anti-Sterolin 2 antibody, anti-STSL antibody, anti-ATP binding cassette G8 antibody. Related Diseases: Atherosclerosis, Coronary Artery Disease

Specificity: ABIN152894 is specific for human ABCG8. Species Reactivity: Human and mouse. Localization: Integral membrane protein, multi-pass membrane protein.

Application Details

Application Notes: Suggested working dilutions: Western Blot 1:250

Concentration: 1 mg/ml

Purification: Purified

Buffer: Preservative: 0.01% sodium azide.

Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Research Area: Cancer, Atherosclerosis, Metabolism

Restrictions: For Research Use only

Publications

Garcia, Wilund, Arca et al.: "Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein." in: Science (New York, N.Y.), Vol. 292, Issue 5520, pp. 1394-8, 2001 (PubMed).

Lu, Lee, Hazard et al.: "Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively." in: American journal of human genetics, Vol. 69, Issue 2, pp. 278-90, 2001 (PubMed).

Schmitz, Langmann, Heimerl: "Role of ABCG1 and other ABCG family members in lipid metabolism." in: Journal of lipid research, Vol. 42, Issue 10, pp. 1513-20, 2001 (PubMed).

Mathur, Watt, Field: "Regulation of intestinal NPC1L1 expression by dietary fish oil and docosahexaenoic acid." in: Journal of lipid research, Vol. 48, Issue 2, pp. 395-404, 2007 (PubMed).