MLX Interacting Protein-Like (MLXIPL) antibody

Details for Product No. ABIN152902
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Antigen
Synonyms ChREBP, WS-bHLH, Wbscr14, bHLHd14, MIO, CHREBP, MONDOB, WBSCR14, MLXIPL
Reactivity
Human
(42), (24), (23), (13), (12), (12), (12)
Host
Rabbit
(44), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(28), (21), (16), (10), (8), (7), (5), (3), (1)
Pubmed 5 references available
Catalog no. ABIN152902
Quantity 0.1 mL
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Immunogen An C-terminal synthetic peptide made to the human ChREBP protein sequence(between residues 800-852). [NCBI# NP_116569.1, isoform 1/alpha].
Specificity This antibody is specific for ChREBP. Species Reactivity: This antibody reacts with human, mouse (see Dentin et al) and rat ChREBP. There is83% homology of the immunogen with the mouse ChREBP protein. Other species havenot been tested.
Cross-Reactivity Human, Rat (Rattus)
Purification Purified
Alternative Name MLXIPL
Background ChREBP is a transcription factor involved in activating genes that encode enzymes offatty acid biosynthesis in liver and adipose. This protein may have relevance to lipidmetabolism, obesity, and type II diabetes. Alternate Names: anti-WBSCR14 antibody, anti-Williams Beuren Syndrome Chromosome Region 14antibody, anti-MIO antibody, anti-MONDOB antibody, anti-WS-bHLH antibody. Related Diseases: Williams-Beuren syndrome, Cancer
Gene ID 51085, 58805, 171078
Application Notes Suggested working dilutions: chromatin immunoprecipitation see #5,immunofluorescence 1:100-1:500
Restrictions For Research Use only
Format Liquid
Concentration 1.2 mg/ml
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-MLX Interacting Protein-Like (MLXIPL) antibody Detection of ChREBP in 20 ug of human hepatocyte lysate using ABIN152902. 5-10 second film exposure.
anti-MLX Interacting Protein-Like (MLXIPL) antibody (2) Immunofluorescent staining of a human hepatocyte using ABIN152902. Overlay staining of ChREBP (rhodamine red) and DAPI nuclear staining (blue).
anti-MLX Interacting Protein-Like (MLXIPL) antibody (3) Detection of ChREBP in liver nuclear extracts from well-fed rats. 7% SDS gel, 1:1,000 dilution of ABIN152902. Photo courtesy of Dr. Uyeda, UT Southwestern University.
General Xu, Christian, Jump: "Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist." in: The Journal of biological chemistry, Vol. 281, Issue 27, pp. 18351-62, 2006 (PubMed).

Wang, Botolin, Xu et al.: "Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity." in: Journal of lipid research, Vol. 47, Issue 9, pp. 2028-41, 2006 (PubMed).

Dentin, Benhamed, Hainault et al.: "Liver-specific inhibition of ChREBP improves hepatic steatosis and insulin resistance in ob/ob mice." in: Diabetes, Vol. 55, Issue 8, pp. 2159-70, 2006 (PubMed).

Erhuma, Salter, Sculley et al.: "Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat." in: American journal of physiology. Endocrinology and metabolism, Vol. 292, Issue 6, pp. E1702-14, 2007 (PubMed).

Aneja, Guha, Shilpi et al.: "The presence of distal and proximal promoters for rat mitochondrial glycerol-3-phosphate acyltransferase." in: Archives of biochemistry and biophysics, Vol. 470, Issue 1, pp. 35-43, 2008 (PubMed).

Hosts (44), (1)
Reactivities (42), (24), (23), (13), (12), (12), (12)
Applications (28), (21), (16), (10), (8), (7), (5), (3), (1)
Conjugates (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (12), (8), (7), (3), (2), (2), (1)
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