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Details for Product No. ABIN152906

Apolipoprotein A-V (APOA5) antibody

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Antigen
Synonyms RAP3, Apoav, 1300007O05Rik, APOAV, apo-AV, apoA-V, APOA5, MGC140487, rap3, apoav, apoa-v
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 2 references available
Catalog no. ABIN152906
Quantity 0.1 mL
Price
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Immunogen Ni-NTA purified full-length recombinant human APOA5 expressed in E. Coli strain BL21(DE3).
Clone 1G5G9
Isotype IgG1
Specificity Species Reactivity: Reacts with human. 83% sequence identity with Bovine, 79% sequence identity withRat, and 78% sequence identity with Mouse proteins.
Cross-Reactivity Human
Purification Ascites
Alternative Name Apolipoprotein A V (ApoA V)
Background Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serumtriglyceride concentrations. An ApoA5 mouse knock-out model produced anapproximately four-fold increase in serum triglycerides, whereas a knock-in model withhuman ApoA5 produced 50-70% lower concentrations of mouse serum triglycerides. Inaddition, peroxisome proliferator-activated receptor-4 (PPAR-alpha) agonists, which areused clinically to lower serum triglyceride concentrations, cause increased ApoA5mRNA expression. Recently, it was demonstrated that ApoA5 is present in humanserum detected by polyclonal antibodies against both the NH2 and COOH termini,although at much lower concentrations than other apolipoproteins. Alternate Names: anti-ApoA5 antibody, anti-Apo-A5 antibody, anti-Apolipoprotein A5 antibody, anti-ApoA-V antibody, anti-Apolipoprotein A-V antibody, anti-ApoA-V antibody. Related Diseases: Coronary Artery Disease, Hypertriglyceridemia
Gene ID 116519
UniProt Q6Q788
Research Area Metabolism
Application Notes Suggested working dilutions: Western Blot 1:500-1:2,000 (ECL). Positive Controls: HEPG2 cells
Restrictions For Research Use only
Format Liquid
Concentration 3.6 mg/ml
Buffer 0.1 ml of crude ascites (3.6 mg/ml) containing 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
Pennacchio, Olivier, Hubacek et al.: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).

Prieur, Coste, Rodriguez: "The human apolipoprotein AV gene is regulated by peroxisome proliferator-activated receptor-alpha and contains a novel farnesoid X-activated receptor response element." in: The Journal of biological chemistry, Vol. 278, Issue 28, pp. 25468-80, 2003 (PubMed).

Alternatives for antigen "Apolipoprotein A-V (APOA5)", type "Antibodies"
Hosts (63), (37), (5)
Reactivities (100), (13), (13), (12), (9)
Applications (82), (74), (10), (7), (7), (5), (2), (1)
Conjugates (5), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (11), (3), (2), (1)
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