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Histone Deacetylase 3 (HDAC3) (AA 411-428) antibody

Details for Product No. ABIN152952
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Antigen
Synonyms CG2128, DHDAC3, DmHDAC3, Dmel\\CG2128, Dromel_CG2128_FBtr0078767_hdac3_mORF, HDAC, HDAC3, Hdac 3, dHDAC3, dmHDA402, hdac3, HDm, hd3, RPD3, XRpd3, rpd3-2, HD3, RPD3-2, AW537363, zgc:55927
Epitope
AA 411-428
(25), (22), (13), (7), (5), (3), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(172), (88), (86), (26), (14), (12), (1), (1), (1), (1), (1), (1)
Host
Rabbit
(137), (38)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Microarray (MA)
(139), (70), (54), (46), (33), (30), (26), (16), (6), (3), (1), (1)
Pubmed 11 references available
Quantity 0.05 mL
Shipping to United States (Change)
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Catalog No. ABIN152952
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Immunogen Synthetic peptide: C-NEFYDGDHDNDKESDVEI conjugated to KLH, corresponding to amino acids 411-428 of human and chicken HDAC3.
Specificity Anti-Histone Deacetylase 3 specifically recognizes histone deacetylase 3 by immunoblotting and immunoprecipitation (50 kD).
Purification IgG purified
Alternative Name HDAC3
Background Histones play a critical role in transcriptional regulation, cell cycle progression, anddevelopmental events. Histone cetylation/deacetylation alters chromosome structureand affects transcription factor access to DNA. The protein encoded by this genebelongs to the histone acetylase/acuc/apha family. It has histone deacetylase activityand represses transcription when tethered to a promoter. It may participate in theregulation of transcription through its binding with the zinc-finger transcription factorYY1. This protein can also down-regulate p53 function and thus modulate cell growthand apoptosis. This gene is regarded as a potential tumor suppressor gene. Alternate Names: Anti-RPD3 2 antibody, Anti-HD 3 antibody, Anti-HD3 antibody, Anti-HDAC 3 antibody,Anti-Histone deacetylase 3 (HD3) (RPD3-2) antibody, Anti-histone deacetylase 3antibody, Anti-RPD 3 antibody, Anti-RPD3 antibody, Anti-RPD3-2 antibody, Anti-SMAP45 antibody, Anti-SMAP45 antibody.
Gene Symbol: HDAC3
Gene ID 8841, 15183, 84578
Research Area Cancer, Hypertrophy, DNA/RNA, Transcription Factors
Application Notes IHC-P: Use human lymph node sections. WB: Use nuclear HeLa human epitheloid carcinoma cells. Predicted molecular weight: 48.8 kDa.
Recommended dilutions: Immunohistochemistry 1:500, Immunohistochemistry-Paraffin 1:500, Immunoprecipitation 1:2500, Microarray, Western Blot 1:2000-1:10000
Restrictions For Research Use only
Format Liquid
Concentration 12.5 mg/mL
Buffer 0.01 M PBS [pH 7.4], Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment -20 °C.
General Wolffe: "Histone deacetylase: a regulator of transcription." in: Science (New York, N.Y.), Vol. 272, Issue 5260, pp. 371-2, 1996 (PubMed).

Taunton, Hassig, Schreiber: "A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p." in: Science (New York, N.Y.), Vol. 272, Issue 5260, pp. 408-11, 1996 (PubMed).

Grunstein: "Histone acetylation in chromatin structure and transcription." in: Nature, Vol. 389, Issue 6649, pp. 349-52, 1997 (PubMed).

Lin, Nagy, Inoue et al.: "Role of the histone deacetylase complex in acute promyelocytic leukaemia." in: Nature, Vol. 391, Issue 6669, pp. 811-4, 1998 (PubMed).

Zhang, LeRoy, Seelig et al.: "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities." in: Cell, Vol. 95, Issue 2, pp. 279-89, 1998 (PubMed).

Tong, Hassig, Schnitzler et al.: "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex." in: Nature, Vol. 395, Issue 6705, pp. 917-21, 1998 (PubMed).

Fischle, Emiliani, Hendzel et al.: "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p." in: The Journal of biological chemistry, Vol. 274, Issue 17, pp. 11713-20, 1999 (PubMed).

Grozinger, Hassig, Schreiber: "Three proteins define a class of human histone deacetylases related to yeast Hda1p." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 9, pp. 4868-73, 1999 (PubMed).

Glaser, Li, Staver et al.: "Role of class I and class II histone deacetylases in carcinoma cells using siRNA." in: Biochemical and biophysical research communications, Vol. 310, Issue 2, pp. 529-36, 2003 (PubMed).

Li, Staver, Curtin et al.: "Expression and functional characterization of recombinant human HDAC1 and HDAC3." in: Life sciences, Vol. 74, Issue 22, pp. 2693-705, 2004 (PubMed).

Furuya, Guigon, Zhao et al.: "Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling." in: Molecular and cellular biology, Vol. 27, Issue 17, pp. 6116-26, 2007 (PubMed).

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