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Details for Product No. ABIN152966

Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer152), (pSer156) antibody

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Synonyms 80K-L, MACS, PKCSL, PRKCSL, Macs, KINC, macs, marcks, wu:fb55c06, wu:fb92d04, wu:fc19b04, wu:fc44a10, zgc:110235, MGC89127, MARCKS
»Alternatives pSer152, pSer156
»Alternatives Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN152966
Quantity 0.1 mL
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Immunogen ABIN152966 was raised against a synthetic phosphopeptide corresponding to aminoacid residues surrounding the phosphorylated Ser 152/156.
Specificity ABIN152966 is specific for the 80 kD MARCKS protein, phosphorylated at Ser152/156. The specificity is defined based on ABIN152966's specific immunolabeling in Westernblots. This labeling is blocked by the phosphopeptide but not the dephosphopeptide.Phosphorylated:Ser152/Ser156. Species Reactivity: ABIN152966 can be used for detection in rat. Other species have not been tested. Localization: Cytoplasmic, actin cytoskeleton.
Cross-Reactivity Rat (Rattus)
Purification Purified
Alternative Name MARCKS
Background Myristolated Alanine-Rich C-Kinase Substrate (MARCKS) is a major in vivo substrate ofprotein kinase C (PKC) and for the lipid-activated PKC-related kinase (PRK1). Furthermore, PRK1 and OPKC phosphorylate MARCKS on the same sites in vitro,serine 152, 156, and 163. MARCKS serves as an in vitro substrate for PKCu as well. However, in contrast to other PKCs, MARCKS is phosphorylated by PKCu only at serine156 and not at serines 152 and 163, implicating a differential regulation by PKCu. Therefore, control of MARCKS phosphorylation on these previously identified 'PKC'sites may be regulated under certain circumstances by PRK as well as PKC mediatedsignaling pathways. MARCKS associates with the plasma membrane in response toPKC-catalyzed phosphorylation of MARCKS. It has been suggested that MARCKS iscapable of associating with the plasma membrane through binding to phospholipidswithout interaction with membranous proteins. Alternate Names: Anti-80K L protein antibody, Anti-80KL antibody, Anti-81 kDa protein, light chainantibody, Anti-MACS antibody, Anti-MARCS antibody, Anti-MGC52672 antibody,Anti-Myristoylated alanine rich protein kinase C substrate antibody,Anti-Phosphomyristin antibody, Anti-PKCSL antibody, Anti-PRKCSL antibody,Anti-Protein kinase C substrate antibody. Related Diseases: Cancer
Application Notes Suggested working dilutions: Western Blot 1:1,000
Restrictions For Research Use only
Format Liquid
Buffer 100 ul of affinity purified anti-MARCKS [0.1 mg/ml] in 10 mM HEPES (pH 7.5), 150 mMNaCl, 100 ug/ml BSA, and 50% glycerol.
Storage -20 °C
Zhang, Ahmed, McFarlane et al.: "Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways." in: Journal of lipid research, Vol. 48, Issue 2, pp. 405-16, 2007 (PubMed).

Alternatives for antigen "Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS)", type "Antibodies"
Hosts (188), (10), (2)
Reactivities (177), (133), (125), (53), (40), (36), (24), (4), (3), (1), (1), (1)
Applications (139), (54), (48), (40), (30), (21), (16), (5), (4), (2), (1), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (27), (25), (23), (22), (21), (9), (7), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)