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Details for Product No. ABIN152984

Antigen Identified By Monoclonal Antibody Ki-67 (MKI67) antibody

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Antigen
Synonyms KIA, MIB-1, Ki67, Ki-67, D630048A14Rik, MKI67, kia, mki67, MGC132156
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 10 references available
Catalog no. ABIN152984
Quantity 0.5 mL
Price
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Immunogen Synthetic peptide from 62 base pair region of the human Ki-67 antigen.
Specificity This antibody reacts with a nuclear antigen present in proliferating human cells. It canbe used to evaluate the Ki-67 labeling index in various tumors. Species Reactivity: Reacts with human, mouse, and porcine. Does not reacts with rat. Localization: Nuclear.
Cross-Reactivity Human, Mouse (Murine), Pig (Porcine)
Purification Purified
Alternative Name Ki-67
Background Ki67 antigen is the prototypic cell cycle related nuclear protein, expressed byproliferating cells in all phases of the active cell cycle (G1, S, G2 and M phase). It isabsent in resting (G0) cells. Ki67 antibodies are useful in establishing the cell growingfraction in neoplasms. In neoplastic tissues the prognostic value is comparable to thetritiated thymidine-labelling index. The correlation between low Ki67 index andhistologically low-grade tumours is strong. Ki67 is routinely used as a neuronal markerof cell cycling and proliferation. Alternate Names: anti-Antigen identified by monoclonal Ki 67 antibody, anti-Antigen KI-67 antibody,anti-KIA antibody, anti-Proliferation related Ki 67 antigen antibody, anti-ki-67 antibody.
Gene ID 4288, 17345, 291234
Research Area Proliferation Markers, Cell Cycle
Application Notes Suggested working dilutions: immunofluorescence 1:20,Immunocytochemistry 1:50,Positive Controls: Tonsil
Restrictions For Research Use only
Concentration 0.1 mg/ml
Buffer PBS + 1% BSA
Storage 4 °C
Gerdes, Li, Schlueter et al.: "Immunobiochemical and molecular biologic characterization of the cell proliferation-associated nuclear antigen that is defined by monoclonal antibody Ki-67." in: The American journal of pathology, Vol. 138, Issue 4, pp. 867-73, 1991 (PubMed).

Knott, Juno, Jarboe et al.: "Smooth muscle overexpression of IGF-I induces a novel adaptive response to small bowel resection." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 287, Issue 3, pp. G562-70, 2004 (PubMed).

Zecchini, Domaschenz, Winton et al.: "Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells." in: Genes & development, Vol. 19, Issue 14, pp. 1686-91, 2005 (PubMed).

Micci, Pattillo, Kahrig et al.: "Caspase inhibition increases survival of neural stem cells in the gastrointestinal tract." in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, Vol. 17, Issue 4, pp. 557-64, 2005 (PubMed).

Kelly, Moeller, Juneja et al.: "The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 21, pp. 8173-8, 2006 (PubMed).

Ip, McGee, Masso-Welch et al.: "The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium." in: Carcinogenesis, Vol. 28, Issue 6, pp. 1269-76, 2007 (PubMed).

Kojima, Vickers, Adsay et al.: "Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia." in: Cancer research, Vol. 67, Issue 17, pp. 8121-30, 2007 (PubMed).

Dai, Freudenberger, Zipper et al.: "Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases." in: The American journal of pathology, Vol. 171, Issue 5, pp. 1451-61, 2007 (PubMed).

Olofsson, Soederstroem, Wuagsaeter et al.: "CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice." in: Circulation, Vol. 117, Issue 10, pp. 1292-301, 2008 (PubMed).

Campa, Gutiuerrez-Lanza, Cerignoli et al.: "Notch activates cell cycle reentry and progression in quiescent cardiomyocytes." in: The Journal of cell biology, Vol. 183, Issue 1, pp. 129-41, 2008 (PubMed).

Alternatives for antigen "Antigen Identified By Monoclonal Antibody Ki-67 (MKI67)", type "Antibodies"
Hosts (119), (76), (6), (2)
Reactivities (193), (33), (26), (1), (1), (1), (1)
Applications (105), (59), (48), (41), (32), (24), (13), (10), (10), (4), (3), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (27), (10), (8), (5), (3), (2), (2), (2), (2), (1), (1), (1)
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