Kinesin Heavy Chain Member 2A (KIF2A) antibody

Details for Product No. ABIN152994
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Antigen
Synonyms kinesin-II, kns2, Kns2, HK2, KIF2, kif2-a, fj55b02, wu:fj55b02
Reactivity
Human, Mammalian, Mouse (Murine), Rat (Rattus)
(16), (7), (6), (3), (2), (2), (2), (1), (1)
Host
Rabbit
(18), (4)
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(22), (7), (5), (5), (5), (3), (2), (2)
Pubmed 4 references available
Catalog no. ABIN152994
Quantity 0.1 mL
Price
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Immunogen Produced by immunizing rabbits with a recombinant segment of the N-terminal domainof the human protein.
Specificity This antibody is specific for Kif2a. Species Reactivity: Reactive to most vertebrate species.
Cross-Reactivity Amphibian, Bird (Avian), Mammalian
Purification Serum
Alternative Name KIF2A
Background Kif2a is a kinesin-like motor protein that depolymerizes microtubules. It is found inseveral vertebrate cell types but is strongly expressed in neuronal cells. In dividing cellsit is required for bipolar spindle formation and chromosome segregation. In neuronalcells it is involved in neurite outgrowth. Alternate Names: anti-KIF2 antibody, anti-KIF-2 antibody, anti-Kinesin Heavy Chain Member.
Gene ID 3796, 16563, 84391
UniProt O00139
Research Area Cytoskeleton
Application Notes Suggested working dilutions: immunofluorescence 1:10000,immunoprecipitation 1:10000,Western Blot 1:10000
Restrictions For Research Use only
Format Liquid
Buffer 0.1 ml of whole rabbit antisera.
Storage -20 °C
Supplier Images
anti-Kinesin Heavy Chain Member 2A (KIF2A) antibody Staining of HeLa cells fixed in 3.5% paraformaldehyde using ABIN152994 (1:5,000). Centrosome staining during interphase and spindle pole staining during mitosis.
General Homma, Takei, Tanaka et al.: "Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension." in: Cell, Vol. 114, Issue 2, pp. 229-39, 2003 (PubMed).

Ganem, Compton: "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK." in: The Journal of cell biology, Vol. 166, Issue 4, pp. 473-8, 2004 (PubMed).

Ferenz, Wadsworth: "Prophase microtubule arrays undergo flux-like behavior in mammalian cells." in: Molecular biology of the cell, Vol. 18, Issue 10, pp. 3993-4002, 2007 (PubMed).

Jang, Wong, Coppinger et al.: "DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement." in: The Journal of cell biology, Vol. 181, Issue 2, pp. 255-67, 2008 (PubMed).

Hosts (18), (4)
Reactivities (16), (7), (6), (3), (2), (2), (2), (1), (1)
Applications (22), (7), (5), (5), (5), (3), (2), (2)
Epitopes (6), (2), (1), (1), (1), (1)
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