Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody

Details for Product No. ABIN153011
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Synonyms API4, EPR-1, AP14, bir5a, survivin, LOC398389, BIRC5, BIR1, Su2, Survivin, Survivin1, XBIR1, api4, epr-1, svv1, xSurvivin1, xsurv, SIX, Su1, svv2, birc5, xSurvivin, xSurvivin2
Human, Mouse (Murine), Rat (Rattus)
(68), (26), (8), (1), (1), (1), (1)
(69), (14), (2)
Clonality (Clone)
Monoclonal ()
Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blotting (WB)
(68), (23), (22), (17), (15), (12), (7), (5), (4), (3), (1), (1), (1), (1), (1)
Pubmed 9 references available
Catalog no. ABIN153011
Quantity 0.1 mL
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Immunogen Full-length recombinant human survivin.
Clone 60-11
Isotype IgG2a
Specificity ABIN153011 is specific for the cytoplasmic form of survivin. Species Reactivity: Human, mouse and rat survivin. Other species have not been tested.
Cross-Reactivity Human
Purification Ascites
Alternative Name IAP4 / BIRC5
Background Regulated inhibition of programmed cell death (apoptosis) preserves normalhomeostasis and tissue and organ morphogenesis. Aberrations in this processcontribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have beenfound in various species, including human. IAP proteins contain one/three Cys/Hisbaculovirus IAP repeats plus a C-terminal RING finger and are thought to block anevolutionary conserved step in apoptosis.Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expressionis turned off during fetal development and is not found in non-neoplastic adult humantissues. Survivin becomes abundantly re-expressed in transformed cells and in all ofthe most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division,governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) ofadult rats following traumatic brain injury. Survivin has been found co-expressed withNeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affectregulation of neural cell proliferative responses after brain injury. Alternate Names: anti-API4 antibody, anti-Apoptosis Inhibitor 4 antibody, anti-Apoptosis inhibitor survivinantibody, anti-Baculoviral IAP repeat containing 5 antibody, anti-BIRC 5 antibody,anti-EPR 1 antibody, anti-IAP4 antibody, anti-SVV antibody, anti-TIAP antibody,anti-BIRC5 antibody.
Gene ID 332, 11799, 64041
UniProt O15392
Research Area Cancer, Apoptosis/Necrosis, Neurology
Application Notes Suggested working dilutions: Western Blot 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 33.6 mg/ml
Buffer 0.01M Na phosphate, 0.25M NaCl [pH 7.6], and 15 mg/ml BSA, 0.01% Thimerisol. Preservative: 0.05% sodium azide.
Preservative Thimerosal (Merthiolate), Sodium azide
Storage -20 °C
Supplier Images
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) antibody Survivin detected in rat aorta smooth muscle cell lysate using ABIN153011.
General Fortugno, Wall, Giodini et al.: "Survivin exists in immunochemically distinct subcellular pools and is involved in spindle microtubule function." in: Journal of cell science, Vol. 115, Issue Pt 3, pp. 575-85, 2002 (PubMed).

Allen, Florell, Hanks et al.: "Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression." in: Cancer research, Vol. 63, Issue 3, pp. 567-72, 2003 (PubMed).

Xu, Zhao, Ding et al.: "Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression." in: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1838-44, 2004 (PubMed).

Ansell, Arendt, Grote et al.: "Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 18, Issue 3, pp. 616-23, 2004 (PubMed).

Ryan, ODonovan, Browne et al.: "Expression of survivin and its splice variants survivin-2B and survivin-DeltaEx3 in breast cancer." in: British journal of cancer, Vol. 92, Issue 1, pp. 120-4, 2005 (PubMed).

Brocardo, Lei, Tighe et al.: "Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival." in: The Journal of biological chemistry, Vol. 283, Issue 9, pp. 5950-9, 2008 (PubMed).

Hino, Uozaki, Inoue et al.: "Survival advantage of EBV-associated gastric carcinoma: survivin up-regulation by viral latent membrane protein 2A." in: Cancer research, Vol. 68, Issue 5, pp. 1427-35, 2008 (PubMed).

Levkau, Schaefers, Wohlschlaeger et al.: "Survivin determines cardiac function by controlling total cardiomyocyte number." in: Circulation, Vol. 117, Issue 12, pp. 1583-93, 2008 (PubMed).

Huang, Fletcher, Beeharry et al.: "Abnormal cytokinesis after X-irradiation in tumor cells that override the G2 DNA damage checkpoint." in: Cancer research, Vol. 68, Issue 10, pp. 3724-32, 2008 (PubMed).

Hosts (69), (14), (2)
Reactivities (68), (26), (8), (1), (1), (1), (1)
Applications (68), (23), (22), (17), (15), (12), (7), (5), (4), (3), (1), (1), (1), (1), (1)
Epitopes (22), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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