CAF-1 Subunit antibody

Details for Product No. ABIN153018
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Antigen
Reactivity
Human
(5), (1)
Host
Mouse
(7)
Clonality (Clone)
Monoclonal ()
Application
Immunoprecipitation (IP), Western Blotting (WB)
(5), (5), (3), (1), (1), (1)
Pubmed 4 references available
Catalog no. ABIN153018
Quantity 0.1 mL
Price
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Immunogen Recombinant human CAF-1p60.
Clone SS53
Isotype IgG1
Specificity Specific for CAF-1p60. Species Reactivity: Recognizes human CAF-1p60. Other species have not been tested. Localization: Nuclear.
Cross-Reactivity Fruit Fly (Drosophila melanogaster), Human, Yeast
Purification Ascites
Background Chromatin assembly factor 1 (CAF-1) is a member of the histone chaperone family. It isrequired for inheritance of epigenetically determined chromosomal states, and in vitro, itpromotes the assembly of chromatin during DNA replication and DNA repair. CAF-1 isa complex of three subunits, p150, p60, and p48. This complex is localized to thenucleus of human cells.Both the composition and the biochemical activity of CAF-1 are conserved amonghuman, yeast, and Drosophila. Alternate Names: anti-p60 CAF1 antibody.
Gene ID 8208
UniProt Q13112
Application Notes Western analysis: A band is seen at 60 kDa representing CAF-1p60. In addition, thisantibody may be used for immunoprecipitation (100-500 ng of IgG).
Restrictions For Research Use only
Format Liquid
Concentration 16.3 mg/ml
Buffer Ascitic fluid. Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage -20 °C
General Smith, Stillman: "Immunological characterization of chromatin assembly factor I, a human cell factor required for chromatin assembly during DNA replication in vitro." in: The Journal of biological chemistry, Vol. 266, Issue 18, pp. 12041-7, 1991 (PubMed).

Shibahara, Stillman: "Replication-dependent marking of DNA by PCNA facilitates CAF-1-coupled inheritance of chromatin." in: Cell, Vol. 96, Issue 4, pp. 575-85, 1999 (PubMed).

Green, Almouzni: "Local action of the chromatin assembly factor CAF-1 at sites of nucleotide excision repair in vivo." in: The EMBO journal, Vol. 22, Issue 19, pp. 5163-74, 2003 (PubMed).

Galvani, Courbeyrette, Agez et al.: "In vivo study of the nucleosome assembly functions of ASF1 histone chaperones in human cells." in: Molecular and cellular biology, Vol. 28, Issue 11, pp. 3672-85, 2008 (PubMed).

Hosts (7)
Reactivities (5), (1)
Applications (5), (5), (3), (1), (1), (1)
Epitopes (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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