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TP53 Apoptosis Effector (PERP) antibody

Antigen

TP53 Apoptosis Effector (PERP)
Synonyms THW, KCP1, PIGPC1, KRTCAP1, 1110017A08Rik, dJ496H19.1, RP3-496H19.1, PERP, thw, kcp1, pigpc1, krtcap1, MGC84230, wu:fk24g11, MGC127602, LOC100221212
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
2 references available
Catalog no. ABIN153033
Quantity 0.1 mg  (1 mg/ml)
Price Product not available in this region.
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Additional Information
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Alternative name PERP
Gene ID 64065
Immunogen Amino acids 37-50 of the human PERP protein.
Cross-Reactivity Human
Description The p53 tumor suppressor activates either cell cycle arrest or apoptosis in response tocellular stress. A novel gene, PERP, is expressed in a p53-dependent manner and athigh levels in apoptotic cells compared with G(1)-arrested cells. PERP induction islinked to p53-dependent apoptosis and is directly activated by p53. These data suggestthat PERP is a novel effector of p53-dependent apoptosis. Alternate Names: anti-PERP antibody, anti-PERP antibody, anti-TP53 apoptosis effectorantibody,anti-HGNC:17637 antibody, anti-KCP1 antibody, anti-KRTCAP1 antibody, anti-PIGPC1antibody, anti-THW antibody, anti-dJ496H19.1antibody, anti-1110017A08Rik antibody,anti-RP3-496H19.1 antibody, anti-keratinocytes associated protein 1antibody.
Specificity Reacts with the first extracellular loop of the human PERP protein. Species Reactivity: Cross reacts with Human. Localization: Cell Membrane, desmosome, multi-pass membrane protein.

Application Details
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Application Notes Suggested working dilutions: Western Blot 1:500 to 1:1000
Concentration 1 mg/ml
Purification Aff - Purified
Buffer PBS. Preservative: 0.02% sodium azide.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
Research Area Signaling, Extracellular Matrix, Apoptosis/Necrosis
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Attardi, Reczek, Cosmas et al.: "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family." in: Genes & development, Vol. 14, Issue 6, pp. 704-18, 2000 (PubMed).

Singaravelu, Devalaraja-Narashimha, Lastovica et al.: "PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia." in: American journal of physiology. Renal physiology, Vol. 296, Issue 4, pp. F847-58, 2009 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "TP53 Apoptosis Effector (PERP)", type "Antibodies"
Hosts Rabbit (37), Goat (4)
Reactivities Human (37), Mouse (Murine) (19), Dog (Canine) (18), Rat (Rattus) (18), Cow (Bovine) (17)
Applications Western Blotting (WB) (24), Immunofluorescence (IF) (16), ELISA (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunocytochemistry (ICC) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (2), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1), Immunohistochemistry (Frozen Sections) (IHC (fro)) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (8), AA 37-50 (3), AA 175-193 (2), Internal Region (1)