TP53 Apoptosis Effector (PERP) antibody

Details for Product No. ABIN153033
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Antigen
Synonyms THW, KCP1, PIGPC1, KRTCAP1, 1110017A08Rik, dJ496H19.1, RP3-496H19.1, PERP, PERPL, kcp1, krtcap1, pigpc1, thw, fk24g11, wu:fk24g11, LOC100221212
Reactivity
Human
(45), (14), (13), (12), (11), (11)
Host
Rabbit
(43), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(37), (14), (11), (9), (8), (4), (4), (1), (1), (1)
Pubmed 2 references available
Catalog no. ABIN153033
Quantity 0.1 mg
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Immunogen Amino acids 37-50 of the human PERP protein.
Specificity Reacts with the first extracellular loop of the human PERP protein. Species Reactivity: Cross reacts with Human. Localization: Cell Membrane, desmosome, multi-pass membrane protein.
Cross-Reactivity Human
Purification Aff - Purified
Alternative Name PERP
Background The p53 tumor suppressor activates either cell cycle arrest or apoptosis in response tocellular stress. A novel gene, PERP, is expressed in a p53-dependent manner and athigh levels in apoptotic cells compared with G(1)-arrested cells. PERP induction islinked to p53-dependent apoptosis and is directly activated by p53. These data suggestthat PERP is a novel effector of p53-dependent apoptosis. Alternate Names: anti-PERP antibody, anti-PERP antibody, anti-TP53 apoptosis effectorantibody,anti-HGNC:17637 antibody, anti-KCP1 antibody, anti-KRTCAP1 antibody, anti-PIGPC1antibody, anti-THW antibody, anti-dJ496H19.1antibody, anti-1110017A08Rik antibody,anti-RP3-496H19.1 antibody, anti-keratinocytes associated protein 1antibody.
Gene ID 64065
Research Area Signaling, Extracellular Matrix, Apoptosis/Necrosis
Application Notes Suggested working dilutions: Western Blot 1:500 to 1:1000
Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS. Preservative: 0.02% sodium azide.
Preservative Sodium azide
Storage 4 °C
General Attardi, Reczek, Cosmas et al.: "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family." in: Genes & development, Vol. 14, Issue 6, pp. 704-18, 2000 (PubMed).

Singaravelu, Devalaraja-Narashimha, Lastovica et al.: "PERP, a p53 proapoptotic target, mediates apoptotic cell death in renal ischemia." in: American journal of physiology. Renal physiology, Vol. 296, Issue 4, pp. F847-58, 2009 (PubMed).

Hosts (43), (5)
Reactivities (45), (14), (13), (12), (11), (11)
Applications (37), (14), (11), (9), (8), (4), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (3), (2), (2), (1), (1), (1)
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