ERK1 / ERK2 (Thr202/Tyr204) antibody

Details for Product No. ABIN153114
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Antigen
Epitope
Thr202/Tyr204
(74), (69), (28), (23), (15), (12), (8), (7), (5), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(219), (150), (141), (83), (78), (71), (47), (24), (9), (9), (9), (3), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(186), (34), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(9), (9), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(162), (59), (44), (43), (39), (32), (21), (18), (10), (4), (3)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
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Catalog No. ABIN153114
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Immunogen Synthetic phospholyrated peptide (KLH coupled) corresponding to residues around Thr202/Tyr204 of human p44 MAP kinase (Erk1 and Erk2)
Specificity This recognises ERK1 phosphorylated at Thr202 and ERK1 phosphorylated at Tyr204.
Cross-Reactivity (Details) Not yet tested in other species.
Purification Whole antisera
Background ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activatedprotein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively.These kinases belong to a family of serine/threonine kinases that are activated upontreatment of cells with a large variety of stimuli including mitogens, hormones, growthfactors, cytokines, and bioactive peptides. Cell stimulation induces the activation of asignaling cascade, the downstream effects of which have been linked to the regulationof cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 arephosphorylated within the activation loop on both a Threonine and a Tyrosine residue(within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevatingthe activity of ERK1&2. Alternate Names: anti-ERT1 antibody, anti-Extracellular signal regulated kinase 1 antibody,anti-Extracellular signal regulated kinase 2 antibody, anti-MAP kinase 2 antibody,anti-MAPK 2 antibody, anti-MAPK 3 antibody, anti-Mitogen activated protein kinase 1antibody, anti-Mitogen activated protein kinase 3 antibody, anti-p42MAPK antibody,anti-p44ERK1 antibody, anti-p44MAPK antibody, anti-PRKM 1 antibody, anti-PRKM 2antibody, anti-PRKM 3 antibody, anti-Protein kinase mitogen activated 1 antibody,anti-Protein kinase mitogen activated 2 antibody, anti-Protein kinase mitogen activated 3antibody, anti-Protein tyrosine kinase ERK 2 antibody.
Gene Symbol: MAPK3
Gene ID 5595, 26417, 50689
Research Area Signaling, Inflammation, Phospho-specific antibodies
Application Notes Predicted molecular weight: 43 kDa.
Recommended dilutions: Immunohistochemistry-Paraffin, Western Blot 1:5000, Immunohistochemistry
Restrictions For Research Use only
Format Liquid
Buffer 50 % Glycerol, PBS
Preservative Without preservative
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
anti-ERK1 / ERK2 (Thr202/Tyr204) antibody Immunohistochemical staining of paraffin-embedded human lung cancer tissue using Zymed Rb anti-phospho-ERK1+2 (Thr202/Tyr204)
General Kolch: "Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions." in: The Biochemical journal, Vol. 351 Pt 2, Issue 2, pp. 289-305, 2001 (PubMed).

Johnson, Lapadat: "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases." in: Science (New York, N.Y.), Vol. 298, Issue 5600, pp. 1911-2, 2002 (PubMed).

Smalley: "A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?" in: International journal of cancer. Journal international du cancer, Vol. 104, Issue 5, pp. 527-32, 2003 (PubMed).

Koleganova, Piecha, Ritz et al.: "Calcitriol ameliorates capillary deficit and fibrosis of the heart in subtotally nephrectomized rats." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 24, Issue 3, pp. 778-87, 2009 (PubMed).

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