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Details for Product No. ABIN153167

WNK Lysine Deficient Protein Kinase 1 (WNK1) antibody

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HSAN2, HSN2, KDP, PRKWNK1, PSK, p65, 6430573H23Rik, EG406236, Hsn2, Prkwnk1, mKIAA0344, ATWNK1, T9J14.14, T9J14_14, ZIK4, with no lysine (K) kinase 1, WNK1, fc14f06, si:ch211-240l19.1, wnk1, wu:fc14f0 ... show more
»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN153167
Quantity 0.1 mL
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Immunogen A synthetic peptide sequence within the C-teminal region of human WNK1 (within thelast 350 amino acids).
Specificity The specificity of this antibody is for WNK1. Species Reactivity: Species reactivity for ABIN153167 has been determined to work in the mouseneuroblastoma x rat dorsal root ganglia, hybridoma, F-11 lysate. There is 100%identity/homology of the immunogen with the human WNK1 protein. There is 91/99%identity/homology of the immunogen with the mouse and rat proteins. Localization: Cytoplasmic.
Alternative Name WNK1
Background WNK kinases play an important role in hypertension. WNK1 is a cytoplasmic proteinthat localizes to a segment of kidney involved in salt, potassium, and pH homeostasis,the distal nephron. Alternate Names: anti-Kinase deficient protein antibody, anti-Protein kinase lysine deficient 1 antibody,anti-Protein kinase with no lysine 1 antibody, anti-Serine/threonine protein kinase WNK1antibody.
Gene ID 65125, 116477
UniProt Q9H4A3
Research Area Signaling, Kinases/Phosphatases
Application Notes Suggested working dilutions: Western Blot 1:1000
Restrictions For Research Use only
Concentration 5 mg/ml
Buffer Preservative: 0.05% sodium azide.
Preservative Sodium azide
Storage -20 °C
Wilson, Disse-Nicodème, Choate et al.: "Human hypertension caused by mutations in WNK kinases." in: Science (New York, N.Y.), Vol. 293, Issue 5532, pp. 1107-12, 2001 (PubMed).

Nuaray-Fejes-Tuoth, Snyder, Fejes-Tuoth: "The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 50, pp. 17434-9, 2004 (PubMed).

Wade, Fang, Liu et al.: "WNK1 kinase isoform switch regulates renal potassium excretion." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 22, pp. 8558-63, 2006 (PubMed).

Alternatives for antigen "WNK Lysine Deficient Protein Kinase 1 (WNK1)", type "Antibodies"
Hosts (78)
Reactivities (75), (48), (47), (24), (24), (24), (12)
Applications (45), (24), (24), (20), (12), (3), (2), (2), (1)
Conjugates (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Epitopes (13), (7), (5), (5), (3), (1), (1), (1), (1)