PR Domain Containing 1, with ZNF Domain (PRDM1) antibody

Details for Product No. ABIN153174
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Antigen
Synonyms BLIMP1, PRDI-BF1, Blimp1, Blimp-1, ZNFPR1A1, GB11750, CG5249, Dmel\\CG5249, blimp-1, dBlimp-1, dBlimp1, nrd, prdm1, ubo, wu:fb99c12, zgc:91885, MGC52536, PRDM1, blimp1, xblimp1, prdi-bf1
Reactivity
Human, Mouse (Murine), Pig (Porcine)
(95), (67), (45), (24), (16), (13), (5)
Host
Mouse
(63), (26), (9), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(87), (63), (27), (26), (17), (17), (10), (9), (4), (1), (1), (1), (1)
Pubmed 11 references available
Catalog no. ABIN153174
Quantity 0.1 mL
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Immunogen A fragment of the mouse Blimp-1 (residues 199-409).
Clone 3H2-E8
Isotype IgG1
Specificity This antibody is specific for the Blimp-1. Species Reactivity: Mouse and human (see Specific Reference). Other species have not been tested. Localization: Nuclear.
Cross-Reactivity Human, Mouse (Murine)
Purification Purified
Alternative Name PRDM1 / BLIMP1
Background Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers inits carboxy terminus. It is a transcriptional repressor that is both required and sufficientto trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1is expressed in, and may be required for terminally differentiated epithelial cells, retinalneurons and other lineage cells. It has also been implicated in the repression ofbeta-interferon (IFN-beta) and c-myc gene expression. Alternate Names: anti-BLIMP 1 antibody, anti-B Lymphocyte Induced Maturation Protein 1 antibody,anti-BLIMP1 antibody, anti-Positive Regulatory Domain I Binding Factor 1 antibody,anti-PR Domain Containing 1 antibody, anti-PRDI BF1 antibody, anti-PRDM1 antibody.
Gene ID 639, 12142
Application Notes Suggested working dilutions: immunohistochemistry 1:200 with tyramide amplification,immunofluorescence 1:200 with tyramide amplification,Western Blot 1:1,000-1:5,000,Immunocytochemistry 1:50-1:100. Positive Controls: P3X (murine plasmocytoma) cell lysates
Restrictions For Research Use only
Format Liquid
Concentration 1.2 mg/ml
Buffer Preservative: 0.1% sodium azide.
Preservative Sodium azide
Storage 4 °C
Supplier Images
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) antibody Detection of Blimp-1 in murine plasmacytoma cell lysate (P3X) using ABIN153174. 1881: murine pre-B cell lysate (negative control). Photo courtesy of DA Savitsky, Columbia University.
anti-PR Domain Containing 1, with ZNF Domain (PRDM1) antibody (2) anti-PR Domain Containing 1, with ZNF Domain (PRDM1) antibody (Image 2)
General Lin, Wong, Calame: "Repression of c-myc transcription by Blimp-1, an inducer of terminal B cell differentiation." in: Science (New York, N.Y.), Vol. 276, Issue 5312, pp. 596-9, 1997 (PubMed).

Angelin-Duclos, Cattoretti, Lin et al.: "Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 10, pp. 5462-71, 2000 (PubMed).

Lin, Angelin-Duclos, Kuo et al.: "Blimp-1-dependent repression of Pax-5 is required for differentiation of B cells to immunoglobulin M-secreting plasma cells." in: Molecular and cellular biology, Vol. 22, Issue 13, pp. 4771-80, 2002 (PubMed).

Chang, Cattoretti, Calame: "The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development." in: Mechanisms of development, Vol. 117, Issue 1-2, pp. 305-9, 2002 (PubMed).

Cattoretti, Angelin-Duclos, Shaknovich et al.: "PRDM1/Blimp-1 is expressed in human B-lymphocytes committed to the plasma cell lineage." in: The Journal of pathology, Vol. 206, Issue 1, pp. 76-86, 2005 (PubMed).

Ohinata, Payer, OCarroll et al.: "Blimp1 is a critical determinant of the germ cell lineage in mice." in: Nature, Vol. 436, Issue 7048, pp. 207-13, 2005 (PubMed).

Severa, Coccia, Fitzgerald: "Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1." in: The Journal of biological chemistry, Vol. 281, Issue 36, pp. 26188-95, 2006 (PubMed).

Gong, Malek: "Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 1, pp. 242-52, 2006 (PubMed).

Liu, Leboeuf, Shi et al.: "Rituximab plus CHOP (R-CHOP) overcomes PRDM1-associated resistance to chemotherapy in patients with diffuse large B-cell lymphoma." in: Blood, Vol. 110, Issue 1, pp. 339-44, 2007 (PubMed).

John, Clements, Russell et al.: "Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1." in: The Journal of biological chemistry, Vol. 283, Issue 2, pp. 951-62, 2008 (PubMed).

Robertson, Charatsi, Joyner et al.: "Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice." in: Development (Cambridge, England), Vol. 134, Issue 24, pp. 4335-45, 2007 (PubMed).

Hosts (63), (26), (9), (2)
Reactivities (95), (67), (45), (24), (16), (13), (5)
Applications (87), (63), (27), (26), (17), (17), (10), (9), (4), (1), (1), (1), (1)
Conjugates (5), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (19), (13), (8), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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