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Details for Product No. ABIN153182

Forkhead Box P3 (FOXP3) antibody

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Synonyms sf, JM2, scurfin, AIID, DIETER, IPEX, PIDX, XPID, RGD1562112, foxp3, FOXP3
»Alternatives Human
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Chromatin Immunoprecipitation (ChIP), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN153182
Quantity 0.1 mg
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Immunogen Synthetic peptide: SQRPSRCSNPTPGP, corresponding to amino acids 418-431 ofHuman FOXP3.
Specificity Species Reactivity: Cross-reacts with Human and monkey. Localization: Nuclear (potential).
Cross-Reactivity Human
Purification Purified
Alternative Name FOXP3
Background FOXP3 (a 381 amino acid protein) is a member of the forkhead/winged-helix family oftranscriptional regulators and is highly conserved across mammals. FOXP3 is essentialfor normal immune homeostasis.FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positiveregulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent inCD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene and amore specific marker of regulatory T cells than other T cells. Alternate Names: anti-FOXP3 antibody, anti-JM2 antibody, anti-AIID antibody, anti-IPEX antibody,anti-PIDX antibody, anti-XPID antibody, anti-DIETER antibody, anti-SCURFIN antibody,anti-forkhead box P3 antibody, anti-scurfin antibody, anti-JM2 protein antibody,anti-immunodeficiency antibody, anti-polyendocrinopathy antibody, anti-enteropathyantibody, anti-X-linked antibody, anti-immune dysregulation antibody,anti-polyendocrinopathy antibody, anti-enteropathy antibody, anti-X-linked antibody,anti-Official Symbol antibody, anti-FOXP3 antibody.
Gene ID 50943
Research Area Immunology, Adaptive Immunity, Transcription Factors
Application Notes Suggested working dilutions: ELISA 1:16000,Immunohistochemistry-Paraffin 0.2-1 ug/ml,Immunohistochemistry-Frozen 0.1-0.2 ug/ml
Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer Tris saline. Preservative: 0.02% Na azide, 0.5% BSA
Preservative Sodium azide
Storage -20 °C
Chatila, Blaeser, Ho et al.: "JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome." in: The Journal of clinical investigation, Vol. 106, Issue 12, pp. R75-81, 2001 (PubMed).

Karube, Ohshima, Tsuchiya et al.: "Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells." in: British journal of haematology, Vol. 126, Issue 1, pp. 81-4, 2004 (PubMed).

Andersson, Boasso, Nilsson et al.: "The prevalence of regulatory T cells in lymphoid tissue is correlated with viral load in HIV-infected patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 6, pp. 3143-7, 2005 (PubMed).

Nilsson, Boasso, Velilla et al.: "HIV-1-driven regulatory T-cell accumulation in lymphoid tissues is associated with disease progression in HIV/AIDS." in: Blood, Vol. 108, Issue 12, pp. 3808-17, 2006 (PubMed).

Schmidt-Lucke, Aicher, Romagnani et al.: "Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients." in: American journal of physiology. Heart and circulatory physiology, Vol. 292, Issue 5, pp. H2425-31, 2007 (PubMed).

Kiniwa, Miyahara, Wang et al.: "CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 23, pp. 6947-58, 2007 (PubMed).

Alternatives for antigen "Forkhead Box P3 (FOXP3)", type "Antibodies"
Hosts (147), (62), (43), (15)
Reactivities (187), (149), (62), (16), (16), (15), (12), (8), (1), (1)
Applications (172), (95), (59), (45), (43), (20), (11), (9), (9), (7), (7), (6), (3), (3), (2)
Conjugates (19), (13), (12), (9), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (53), (14), (7), (7), (7), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)