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Details for Product No. ABIN153185

Forkhead Box P3 (FOXP3) antibody

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Synonyms sf, JM2, scurfin, AIID, DIETER, IPEX, PIDX, XPID, RGD1562112, foxp3, FOXP3
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN153185
Quantity 0.1 mL
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Immunogen A synthetic peptide made to the C-terminal region of human FOXP3 (between residues400-431).
Specificity This antibody is specific for human FOXP3. Species Reactivity: Human. This antibody does not appear to detect the mouse FOXP3 protein by westernblot, but does work on mouse tissue for IHC (see data below). Other species have notbeen tested.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name FOXP3
Background FOXP3 is a member of the forkhead/winged-helix family of transcriptional regulators andis highly conserved across mammals. FOXP3 is essential for normal immunehomeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positiveregulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent inCD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene and amore specific marker of regulatory T cells than other T cells. Alternate Names: anti-FOXP3 antibody, anti-JM2 antibody, anti-AIID antibody, anti-IPEX antibody,anti-PIDX antibody, anti-XPID antibody, anti-DIETER antibody, anti-SCURFIN antibody,anti-forkhead box P3 antibody, anti-scurfin antibody, anti-JM2 protein antibody,anti-immunodeficiency antibody, anti-polyendocrinopathy antibody, anti-enteropathyantibody, anti-X-linked antibody, anti-immune dysregulation antibody,anti-polyendocrinopathy antibody, anti-enteropathy antibody, anti-X-linked antibody,anti-Official Symbol antibody, anti-FOXP3 antibody.
Gene ID 50943, 20371
UniProt Q9BZS1
Research Area Immunology, Adaptive Immunity, Transcription Factors
Application Notes Suggested working dilutions: immunohistochemistry -Fr 1/50,Western Blot 1/1000-1/5000 (ECL)
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/ml
Buffer Tris-citrate/phosphate [pH 7-8]. Preservative: Sodium Azide.
Preservative Sodium azide
Storage 4 °C
Polanczyk, Carson, Subramanian et al.: "Cutting edge: estrogen drives expansion of the CD4+CD25+ regulatory T cell compartment." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 173, Issue 4, pp. 2227-30, 2004 (PubMed).

Ochs, Ziegler, Torgerson: "FOXP3 acts as a rheostat of the immune response." in: Immunological reviews, Vol. 203, pp. 156-64, 2005 (PubMed).

Ochando, Yopp, Yang et al.: "Lymph node occupancy is required for the peripheral development of alloantigen-specific Foxp3+ regulatory T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 174, Issue 11, pp. 6993-7005, 2005 (PubMed).

Ostroukhova, Qi, Oriss et al.: "Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta." in: The Journal of clinical investigation, Vol. 116, Issue 4, pp. 996-1004, 2006 (PubMed).

Alternatives for antigen "Forkhead Box P3 (FOXP3)", type "Antibodies"
Hosts (146), (62), (43), (16)
Reactivities (187), (148), (62), (16), (16), (15), (12), (8), (1), (1)
Applications (172), (95), (60), (45), (43), (20), (10), (9), (9), (7), (7), (6), (3), (3), (3)
Conjugates (19), (13), (12), (9), (6), (6), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (53), (14), (7), (7), (7), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)