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Details for Product No. ABIN153322

Collagen, Type I (COL1) antibody

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»Alternatives Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN153322
Quantity 50 µg
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Immunogen Collagen Type I from human and bovine placenta by limited pepsin digestion andselective salt precipitation.
Specificity Typically less than 1% cross reactivity against other types of collagens was detected byELISA against purified standards. This antibody reacts with most mammalian Type Icollagens. Minimum Cross Reactivity to Type II, III, IV, V and VI Collagens. Species Reactivity: Reacts with human and rat. Expected to react with most mammalian Type I collagens. Localization: Extracellular matrix.
Cross-Reactivity Mammalian
Purification Purified
Alternative Name Collagen type I
Background Collagens are highly conserved throughout evolution and are characterized by anuninterrupted Glycine-X-Y triplet repeat that is a necessary part of the triple helicalstructure. For these reasons it is often extremely difficult to generate antibodies withspecificities to collagens. The development of type specific antibodies is dependent onNON-DENATURED three-dimensional epitopes. This preparation results in a nativeconformation of the protein. Alternate Names: Anti-COL1A1 antibody, Anti-Collagen Of Skin Tendon And Bone antibody, Anti-CollagenType 1 antibody, Anti-OI4 antibody, Anti- Osteogenesis Imperfecta Type IV antibody,Anti-Pro alpha 1(I) collagen antibody.
Gene ID 1277, 29393
Research Area Extracellular Matrix
Application Notes Suggested working dilutions: ELISA - 1:5,000-1:50,000,Western Blot - 1:5,000-1:50,000,Immunohistochemistry-Frozen - 1:50-1:200
Restrictions For Research Use only
Concentration 1.17 mg/ml
Buffer 0.125M Sodium Borate, 0.075M Sodium Chloride, 0.005M EDTA [pH8]. Preservative: 0.01% sodium azide.
Preservative Sodium azide
Storage 4 °C
Stefanovic, Schnabl, Brenner: "Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy." in: The Journal of biological chemistry, Vol. 277, Issue 20, pp. 18229-37, 2002 (PubMed).

Hazra, Xiong, Wang et al.: "Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells." in: The Journal of biological chemistry, Vol. 279, Issue 12, pp. 11392-401, 2004 (PubMed).

Hashimoto, Jin, Liu et al.: "Bone marrow-derived progenitor cells in pulmonary fibrosis." in: The Journal of clinical investigation, Vol. 113, Issue 2, pp. 243-52, 2004 (PubMed).

She, Xiong, Hazra et al.: "Adipogenic transcriptional regulation of hepatic stellate cells." in: The Journal of biological chemistry, Vol. 280, Issue 6, pp. 4959-67, 2005 (PubMed).

Keophiphath, Achard, Henegar et al.: "Macrophage-secreted factors promote a profibrotic phenotype in human preadipocytes." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 1, pp. 11-24, 2009 (PubMed).

Alternatives for antigen "Collagen, Type I (COL1)", type "Antibodies"
Hosts (140), (37), (26), (2), (1)
Reactivities (113), (36), (28), (22), (15), (11), (10), (8), (6), (6), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Applications (181), (101), (95), (71), (66), (56), (53), (45), (20), (17), (15), (4), (3), (3), (1), (1), (1)
Conjugates (24), (1)
Epitopes (1), (1)