Collagen, Type I (COL1) antibody

Details for Product No. ABIN153357
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Antigen
Reactivity
Cow (Bovine), Human, Mammalian, Pig (Porcine), Rabbit, Rat (Rattus)
(145), (73), (64), (43), (25), (21), (14), (11), (8), (6), (6), (4), (2), (2), (2), (2), (2), (2), (1), (1)
Host
Mouse
(178), (31), (25), (2), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(25), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Dot Blot (DB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(190), (113), (107), (93), (65), (61), (59), (29), (21), (20), (19), (3), (3), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN153357
Quantity 0.1 mL
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Immunogen Full length bovine native protein (purified).
Clone COL-1
Isotype IgG1
Specificity Recognizes the native (helical) form of collagen type I using ELISA and dot-blot. Doesnot react with the thermally-denatured molecule. The antibody shows nocross-reactivity with collagen types II, III, IV, V, VI, VII, IX, X and XI. Species Reactivity: Cross-reacts with Cow, Human, Pig, Rabbit, Deer and Rat. Not yet tested in otherspecies. Localization: Extracellular matrix.
Cross-Reactivity Cow (Bovine), Human, Pig (Porcine), Rabbit, Rat (Rattus)
Purification Purified
Alternative Name Collagen type I
Background The extracellular matrix is the material found in the extracellular environment of alltissues and organs. It consists of basement membranes and interstitial stroma. Thecomposition of the extracellular framework of all vertebrates is dominated by a class ofmolecules known as collagens,1 each with unique features suited for its function andlocation. The collagens are proteins composed of three subunit polypeptides that canvary in length, which interact to form a triple helix. The molecular basis of the triple helixis provided by a repeated unique amino acid sequence (Gly-x-y) and the polypeptidesgenerated are capable of assembly into fibrillar or other types of supramolecularassemblies which are deposited in the extracellular matrix. The number of distinctcollagen types presently recognized is more than fourteen. Type I collagen [. Alternate Names: Anti-COL1A1 antibody, Anti-Collagen Of Skin Tendon And Bone antibody, Anti-CollagenType 1 antibody, Anti-OI4 antibody, Anti-Osteogenesis Imperfecta Type IV antibody,Anti-Pro alpha 1(I) collagen antibody, anti-Collagen I.
Gene ID 1277, 29393
Research Area Extracellular Matrix
Application Notes Suggested working dilutions: ELISA : use at an assay dependent dilution,immunohistochemistry 1:2000,Western Blot
Restrictions For Research Use only
Format Liquid
Concentration 5.8 mg/ml
Buffer Ascitic fluid
Storage 4 °C
General Sanes, Engvall, Butkowski et al.: "Molecular heterogeneity of basal laminae: isoforms of laminin and collagen IV at the neuromuscular junction and elsewhere." in: The Journal of cell biology, Vol. 111, Issue 4, pp. 1685-99, 1990 (PubMed).

Werkmeister, Ramshaw: "Monoclonal antibodies to collagens for immunofluorescent examination of human skin." in: Acta dermato-venereologica, Vol. 69, Issue 5, pp. 399-402, 1989 (PubMed).

Gay, Fine: "Characterization and isolation of poly- and monoclonal antibodies against collagen for use in immunohistochemistry." in: Methods in enzymology, Vol. 145, pp. 148-67, 1987 (PubMed).

Hosts (178), (31), (25), (2), (1)
Reactivities (145), (73), (64), (43), (25), (21), (14), (11), (8), (6), (6), (4), (2), (2), (2), (2), (2), (2), (1), (1)
Applications (190), (113), (107), (93), (65), (61), (59), (29), (21), (20), (19), (3), (3), (1), (1), (1), (1)
Conjugates (25), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Epitopes (14), (2), (1), (1)
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