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Details for Product No. ABIN153416

Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody

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AAT6, ACTSA, MYMY5, 0610041G09Rik, Actvs, SMalphaA, a-SMA, alphaSMA, wu:fb63d03, asma, ASMA, SMactin, a-sma, aat6, actsa, mymy5, sm-actin, ACTA2, actc1, ACT-4, acta, cftd, mpfd, nem1, nem2, nem3, acta ... show more
»Alternatives Human
»Alternatives Rabbit
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 1 reference available
Catalog no. ABIN153416
Quantity 0.5 mL
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Immunogen Synthetic peptide corresponding to N-terminus of human alpha smooth muscle isoformof actin.
Specificity This antibody stains smooth muscle cells in vessel walls, gut wall, and myometrium.Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumorsarising from smooth muscles and myoepithelial cells. Species Reactivity: Cross-reacts with Baboon, Chicken, Cow, Human, Mouse, Rabbit and Rat. Not yettested in other species. Localization: Cytoplasmic.
Cross-Reactivity Chicken, Mammalian
Purification Affinity Purified
Alternative Name Aortic smooth muscle Actin / ACTA2
Background Actins are highly conserved proteins expressed in all eukaryotic cells. Actin filamentsform part of the cytoskeleton and play essential roles in regulating cell shape andmovement. Six distinct actin isotypes have been identified in mammalian cells. Each isencoded by a separated gene and is expressed in a developmentally regulated andtissue-specific manner, alpha and beta cytoplasmic actins are expressed in a widevariety of cells, whereas, expression of alpha skeletal, alpha cardiac, alpha vascular,and gamma enteric actins are more restricted to specialized muscle cell type. Smoothmuscle alpha actin is of further interest because it is one of a few genes whoseexpression is relatively restricted to vascular smooth muscle cells. Further more,expression of smooth muscle alpha actin is regulated by hormones, cell proliferation ,and altered by pathological conditions including oncogenic transformation andatherosclerosis. Alternate Names: anti-Smooth Muscle Actin antibody.
Gene ID 59, 25365
Research Area Extracellular Matrix, Cell/Tissue Markers
Application Notes Suggested working dilutions: ELISA 0.1 - 1.0 ug/ml,Western Blot 0.5 - 2.0 ug/ml,Immunohistochemistry-Paraffin 1/100-1/400
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/ml
Buffer PBS [pH 7.4]. Preservative: 0.09% sodium azide.
Preservative Sodium azide
Storage 4 °C
Jeyasuria, Wetzel, Bradley et al.: "Progesterone-regulated caspase 3 action in the mouse may play a role in uterine quiescence during pregnancy through fragmentation of uterine myocyte contractile proteins." in: Biology of reproduction, Vol. 80, Issue 5, pp. 928-34, 2009 (PubMed).

Alternatives for antigen "Actin, alpha 2, Smooth Muscle, Aorta (ACTA2)", type "Antibodies"
Hosts (84), (48), (6), (1)
Reactivities (114), (42), (40), (17), (15), (12), (8), (7), (7), (6), (3), (3), (1), (1), (1), (1)
Applications (76), (72), (39), (37), (34), (15), (13), (12), (10), (7), (5), (2), (2), (2), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (47), (2), (2), (1), (1), (1), (1), (1)