Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody

Details for Product No. ABIN153416
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Antigen
Synonyms
AAT6, ACTSA, MYMY5, 0610041G09Rik, Actvs, SMalphaA, a-SMA, alphaSMA, wu:fb63d03, asma, ASMA, SMactin, a-sma, aat6, actsa, mymy5, sm-actin, ACTA2, actc1, ACT-4, acta, cftd, mpfd, nem1, nem2, nem3, acta ... show more
AAT6, ACTSA, MYMY5, 0610041G09Rik, Actvs, SMalphaA, a-SMA, alphaSMA, wu:fb63d03, asma, ASMA, SMactin, a-sma, aat6, actsa, mymy5, sm-actin, ACTA2, actc1, ACT-4, acta, cftd, mpfd, nem1, nem2, nem3, acta2, cftd1, cftdm, MGC52636, MGC79039, MGC89192 show less
Reactivity
Human
(132), (54), (40), (15), (15), (14), (7), (6), (5), (3), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(90), (57), (5), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(6), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(97), (62), (57), (47), (33), (22), (19), (17), (5), (4), (2), (2), (1), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN153416
Quantity 0.5 mL
Price
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Immunogen Synthetic peptide corresponding to N-terminus of human alpha smooth muscle isoformof actin.
Specificity This antibody stains smooth muscle cells in vessel walls, gut wall, and myometrium.Myoepithelial cells in breast and salivary gland are also stained. It reacts with tumorsarising from smooth muscles and myoepithelial cells. Species Reactivity: Cross-reacts with Baboon, Chicken, Cow, Human, Mouse, Rabbit and Rat. Not yettested in other species. Localization: Cytoplasmic.
Cross-Reactivity Chicken, Mammalian
Purification Affinity Purified
Alternative Name Aortic smooth muscle Actin / ACTA2
Background Actins are highly conserved proteins expressed in all eukaryotic cells. Actin filamentsform part of the cytoskeleton and play essential roles in regulating cell shape andmovement. Six distinct actin isotypes have been identified in mammalian cells. Each isencoded by a separated gene and is expressed in a developmentally regulated andtissue-specific manner, alpha and beta cytoplasmic actins are expressed in a widevariety of cells, whereas, expression of alpha skeletal, alpha cardiac, alpha vascular,and gamma enteric actins are more restricted to specialized muscle cell type. Smoothmuscle alpha actin is of further interest because it is one of a few genes whoseexpression is relatively restricted to vascular smooth muscle cells. Further more,expression of smooth muscle alpha actin is regulated by hormones, cell proliferation ,and altered by pathological conditions including oncogenic transformation andatherosclerosis. Alternate Names: anti-Smooth Muscle Actin antibody.
Gene ID 59, 25365
Research Area Extracellular Matrix, Cell/Tissue Markers
Application Notes Suggested working dilutions: ELISA 0.1 - 1.0 ug/ml,Western Blot 0.5 - 2.0 ug/ml,Immunohistochemistry-Paraffin 1/100-1/400
Restrictions For Research Use only
Format Liquid
Concentration 0.2 mg/ml
Buffer PBS [pH 7.4]. Preservative: 0.09% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Supplier Images
anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody Formalin-fixed, paraffin-embedded Human Leiomyoma stained with ABIN153416
General Jeyasuria, Wetzel, Bradley et al.: "Progesterone-regulated caspase 3 action in the mouse may play a role in uterine quiescence during pregnancy through fragmentation of uterine myocyte contractile proteins." in: Biology of reproduction, Vol. 80, Issue 5, pp. 928-34, 2009 (PubMed).

Hosts (90), (57), (5), (1)
Reactivities (132), (54), (40), (15), (15), (14), (7), (6), (5), (3), (3), (2), (1), (1), (1), (1)
Applications (97), (62), (57), (47), (33), (22), (19), (17), (5), (4), (2), (2), (1), (1), (1)
Conjugates (6), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (62), (2), (2), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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