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Actin, beta (ACTB) antibody
Human, Mouse (Murine)
Alternatives Western Blotting (WB)
|3 references available|
|Quantity||25 µL (1 mg/ml) (Variants)|
|Price||Product not available in this region.|
|Alternative name||Actin beta / ACTB|
|Immunogen||The epitope that this antibody recognizes maps to the N-terminus of human beta actinusing the numbering given in Swiss-prot entry P60709. The N-terminus of beta actin ishighly conserved with gamma actin. Initial tests show that this antibody recognizes bothbeta and gamma actin.|
|Cross-Reactivity||Human, Mouse (Murine)|
|Description||In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have beenidentified. The alpha actins are found in muscle tissues and are a major constituent ofthe contractile apparatus. The beta and gamma actins coexist in most cell types ascomponents of the cyto-skeleton and as mediators of internal cell motility. Beta actinsare highly conserved proteins that are involved in cell motility, structure and integrity.Beta actins are cytoplasmic proteins ubiquitously expressed in all eukaryotic cells.Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in theform of a two-stranded helix. Each actin can bind to 4 others. This antibody serves as anexcellent loading control. Alternate Names: anti-ActG antibody, anti-ActG1 antibody, anti-Actin antibody, anti-Gamma1 antibody,anti-DFNA20 antibody, anti-A X actin like protein antibody, anti-Actx antibody, Anti-Betacytoskeletal actin antibody, Anti-Melanoma X actin antibody, anti-PS1TP5BP1 antibody.|
|Specificity||Detects a single clean band at 40kD representing actin. Species Reactivity: Human and Mouse.|
|Synonyms||PS1TP5BP1, Actx, beta-actin, E430023M04Rik, ACTB, MGC128179, MGC76228, MGC79692, MGC88999, ps1tp5bp1, LOC442937, LOC563571, A26C1A, A26C1B, ACT-5, act-2, Actb, actb, B-actin, LOC100136013, DKFZp459A196, LOC100174883, LOC100304816, ACTA1|
|Application Notes||Suggested working dilutions: Western Blot 1:5,000-1:15,000|
|Buffer||Tris-citrate/phosphate pH 7 to 8. Preservative: 0.09% Sodium Azide.|
|Storage||Store at 4C. Do not freeze.|
|Restrictions||For Research Use only|
|anti-Actin, beta (ACTB) antibody|
Watters, Kraja, Meucci et al.: "Genome-wide discovery of loci influencing chemotherapy cytotoxicity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 32, pp. 11809-14, 2004 (PubMed).
Sanue, Sinnett, Delvin et al.: "Localization and role of NPC1L1 in cholesterol absorption in human intestine." in: Journal of lipid research, Vol. 47, Issue 10, pp. 2112-20, 2006 (PubMed).
Kolokoltsov, Deniger, Fleming et al.: "Small interfering RNA profiling reveals key role of clathrin-mediated endocytosis and early endosome formation for infection by respiratory syncytial virus." in: Journal of virology, Vol. 81, Issue 14, pp. 7786-800, 2007 (PubMed).