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Details for Product No. ABIN153606

Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody

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Antigen
Synonyms CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, C85791, Cd31, Pecam
Reactivity
»Alternatives Human, Monkey
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Flow Cytometry (FACS), Immunoprecipitation (IP)
Pubmed 4 references available
Catalog no. ABIN153606
Quantity 0.1 mg
Price
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Immunogen Cellular Location: Cell surface antigen expressed by platelets, endothelial cells, granulocytes and somelymphocytes. Epitope: Maps to domain 2 of CD31 as defined on p364 of Leukocyte Typing VI.
Clone WM59
Isotype IgG1
Specificity This antibody recognizes the human CD31 cell surface antigen. CD31 is also known asPECAM-1 and has a MW of 130 kD. Species Reactivity: Cross-reacts with Human. It does not cross-react with rat. Not yet tested in otherspecies. Localization: Cell surface antigen expressed by platelets, endothelial cells, granulocytes and somelymphocytes.
Cross-Reactivity Human
Purification Affinity Purified
Alternative Name CD31 / PECAM1
Background CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a typeI integral membrane glycoprotein and a member of the immunoglobulin superfamily ofcell surface receptors. It is constitutively expressed on the surface of endothelial cells,and concentrated at the junction between them. It is also weakly expressed on manyperipheral lymphoid cells and platelets. CD31 has been used to measure angiogenesisin association with tumor recurrence. Other studies have also indicated that CD31 andCD34 can be used as markers for myeloid progenitor cells and recognize differentsubsets of myeloid leukemia infiltrates (granular sarcomas). Alternate Names: anti-CSPG6 - Chondroitin Sulfate Proteoglycan 6 antibody, anti-BAM - Bamacanantibody, anti-HCAP - Human Chromosome- Associated Polypeptide antibody.
Gene ID 5175, 29583
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Suggested working dilutions: flow cytometry / FACS analysis 1/50 - 1/100
Restrictions For Research Use only
Concentration 1.0 mg/ml
Buffer PBS. Preservative: sodium azide.
Preservative Sodium azide
Storage 4 °C
Stockinger, Gadd, Eher et al.: "Molecular characterization and functional analysis of the leukocyte surface protein CD31." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 11, pp. 3889-97, 1991 (PubMed).

Cabañas, Sanchez-Madrid, Bellon et al.: "Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells." in: European journal of immunology, Vol. 19, Issue 8, pp. 1373-8, 1989 (PubMed).

DeLisser, Newman, Albelda: "Molecular and functional aspects of PECAM-1/CD31." in: Immunology today, Vol. 15, Issue 10, pp. 490-5, 1994 (PubMed).

Adriaenssens, Vanhecke, Saule et al.: "Nerve growth factor is a potential therapeutic target in breast cancer." in: Cancer research, Vol. 68, Issue 2, pp. 346-51, 2008 (PubMed).

Alternatives for antigen "Platelet/endothelial Cell Adhesion Molecule (PECAM1)", type "Antibodies"
Hosts (316), (136), (86), (4), (3), (1)
Reactivities (386), (180), (70), (43), (30), (23), (12), (10), (3), (2), (1)
Applications (318), (187), (120), (93), (89), (71), (68), (48), (28), (25), (20), (19), (9), (8), (4), (4), (2), (2), (1), (1), (1), (1)
Conjugates (56), (50), (33), (19), (9), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Epitopes (35), (6), (5), (5), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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