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Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody

Details for Product No. ABIN153606
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Antigen
Synonyms CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM, C85791, Cd31, Pecam
Reactivity
Human, Monkey
(378), (184), (67), (41), (30), (20), (11), (5), (2), (1)
Host
Mouse
(290), (154), (80), (4), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(55), (46), (30), (19), (9), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
(294), (196), (115), (109), (92), (70), (60), (51), (36), (24), (19), (5), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN153606
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Immunogen Made to Human CD31
Clone WM59
Isotype IgG1
Specificity This recognizes the human CD31 cell surface antigen.
Cross-Reactivity (Details) Cross reacts with Cynomolgus Monkey,Rhesus Monkey.
Purification Protein G purified
Alternative Name CD31 / PECAM1
Background CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a typeI integral membrane glycoprotein and a member of the immunoglobulin superfamily ofcell surface receptors. It is constitutively expressed on the surface of endothelial cells,and concentrated at the junction between them. It is also weakly expressed on manyperipheral lymphoid cells and platelets. CD31 has been used to measure angiogenesisin association with tumor recurrence. Other studies have also indicated that CD31 andCD34 can be used as markers for myeloid progenitor cells and recognize differentsubsets of myeloid leukemia infiltrates (granular sarcomas). Alternate Names: anti-CSPG6 - Chondroitin Sulfate Proteoglycan 6 antibody, anti-BAM - Bamacanantibody, anti-HCAP - Human Chromosome- Associated Polypeptide antibody.
Gene Symbol: PECAM1
Gene ID 5175, 29583
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow cytometry: Use 10 ul of the working dilution to label 10^6 cells. Immunohistochemistry-Frozen and Immunocytochemistry/Immunofluorescence were reported in scientific literature.
Recommended dilutions: Flow Cytometry 1:50-1:100, Immunocytochemistry/Immunofluorescence 1:10-1:500, Immunohistochemistry 1:10-1:500, Immunohistochemistry-Frozen 1:10-1:500, Immunoprecipitation 1:10-1:500
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS, pH 7.4, Sodium Azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles
Storage 4 °C
Storage Comment 4 °C short term. Aliquot and store at -20 °C long term.
Supplier Images
anti-Platelet/endothelial Cell Adhesion Molecule (PECAM1) antibody Staining of human peripheral blood lymphocytes with MOUSE ANTI HUMAN CD31.
General Stockinger, Gadd, Eher et al.: "Molecular characterization and functional analysis of the leukocyte surface protein CD31." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 145, Issue 11, pp. 3889-97, 1991 (PubMed).

Cabañas, Sanchez-Madrid, Bellon et al.: "Characterization of a novel myeloid antigen regulated during differentiation of monocytic cells." in: European journal of immunology, Vol. 19, Issue 8, pp. 1373-8, 1989 (PubMed).

DeLisser, Newman, Albelda: "Molecular and functional aspects of PECAM-1/CD31." in: Immunology today, Vol. 15, Issue 10, pp. 490-5, 1994 (PubMed).

Adriaenssens, Vanhecke, Saule et al.: "Nerve growth factor is a potential therapeutic target in breast cancer." in: Cancer research, Vol. 68, Issue 2, pp. 346-51, 2008 (PubMed).

Validation Images
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