HUS1 antibody (C-Term)

Catalog No. ABIN1536829

Product Details anti-HUS1 Antibody

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Binding Specificity: AA 199-226, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HUS1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HUS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-226 amino acids from the C-terminal region of human HUS1.

Clone: RB36257

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: HUS1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for HUS1

Target: HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))

Alternative Name: HUS1 (HUS1 Products)

Synonyms: hHUS1 antibody, mHus1 antibody, XHus1 antibody, hus1 antibody, HUS1 checkpoint clamp component antibody, checkpoint clamp complex protein Hus1 antibody, HUS1 checkpoint clamp component L homeolog antibody, HUS1 antibody, Hus1 antibody, hus1 antibody, hus1.L antibody

Background: The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. [provided by RefSeq].

Molecular Weight: 31691

Gene ID: 3364

NCBI Accession: NP_004498

UniProt: O60921