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Macrophage Scavenger Receptor 1 antibody (C-Term)

MSR1 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB36746 unconjugated
Catalog No. ABIN1537159
  • Target See all Macrophage Scavenger Receptor 1 (MSR1) Antibodies
    Macrophage Scavenger Receptor 1 (MSR1)
    Binding Specificity
    • 16
    • 7
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 336-364, C-Term
    Reactivity
    • 61
    • 57
    • 18
    • 16
    • 8
    • 8
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 59
    • 16
    • 5
    Rabbit
    Clonality
    • 58
    • 18
    Polyclonal
    Conjugate
    • 32
    • 8
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Macrophage Scavenger Receptor 1 antibody is un-conjugated
    Application
    • 60
    • 35
    • 30
    • 14
    • 13
    • 13
    • 12
    • 10
    • 9
    • 7
    • 5
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This MSR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human MSR1.
    Clone
    RB36746
    Isotype
    Ig Fraction
    Top Product
    Discover our top product MSR1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    MSR1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Chen, Li, Zhu: "AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-?B/LOX-1 pathway." in: Vascular pharmacology, (2015) (PubMed).

  • Target
    Macrophage Scavenger Receptor 1 (MSR1)
    Alternative Name
    MSR1 (MSR1 Products)
    Synonyms
    CD204 antibody, SCARA1 antibody, SR-A antibody, SRA antibody, phSR1 antibody, phSR2 antibody, MRS-A antibody, MSR antibody, MSR-A antibody, SR-AI antibody, SR-AII antibody, Scara1 antibody, Scvr antibody, MSR1 antibody, RGD1564316 antibody, macrophage scavenger receptor 1 antibody, scavenger receptor class A member 5 antibody, MSR1 antibody, Msr1 antibody, SCARA5 antibody
    Background
    This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
    Molecular Weight
    49762
    Gene ID
    4481
    NCBI Accession
    NP_002436, NP_619729, NP_619730
    UniProt
    P21757
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