DEFa3 antibody (C-Term)

Catalog No. ABIN1537232

Product Details anti-DEFa3 Antibody

Target: DEFa3 (Defensin, alpha 3, Neutrophil-Specific (DEFa3))

Binding Specificity: AA 38-65, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DEFa3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DEFA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-65 amino acids from the C-terminal region of human DEFA3.

Clone: RB30594

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: DEFA3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for DEFa3

Target: DEFa3 (Defensin, alpha 3, Neutrophil-Specific (DEFa3))

Alternative Name: DEFA3 (DEFa3 Products)

Synonyms: Defa27 antibody, Defcr-3 antibody, Defcr3 antibody, DEF3 antibody, HNP-3 antibody, HNP3 antibody, HP-3 antibody, HP3 antibody, defensin, alpha 3, neutrophil-specific antibody, defensin, alpha, 3 antibody, defensin alpha 3 antibody, DEFA3 antibody, Defa3 antibody

Background: Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.

Molecular Weight: 10245

Gene ID: 1668

NCBI Accession: NP_005208

UniProt: P59666

Pathways: Cellular Response to Molecule of Bacterial Origin