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POLR3C antibody (AA 202-230)

POLR3C Reactivity: Human WB Host: Rabbit Polyclonal RB36947 unconjugated
Catalog No. ABIN1538053
  • Target See all POLR3C Antibodies
    POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
    Binding Specificity
    • 15
    • 9
    • 8
    • 6
    • 6
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 202-230
    Reactivity
    • 47
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Host
    • 43
    • 4
    Rabbit
    Clonality
    • 46
    • 1
    Polyclonal
    Conjugate
    • 19
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This POLR3C antibody is un-conjugated
    Application
    • 42
    • 21
    • 13
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This POLR3C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of human POLR3C.
    Clone
    RB36947
    Isotype
    Ig Fraction
    Top Product
    Discover our top product POLR3C Primary Antibody
  • Application Notes
    WB: 1:1000. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    POLR3C Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Target
    POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))
    Alternative Name
    POLR3C (POLR3C Products)
    Synonyms
    rpc3 antibody, rpc62 antibody, 4933407E01Rik antibody, RPC3 antibody, RPC62 antibody, zgc:56348 antibody, polymerase (RNA) III (DNA directed) polypeptide C (62kD) S homeolog antibody, RNA polymerase III subunit C antibody, polymerase (RNA) III (DNA directed) polypeptide C (62kD) antibody, polymerase (RNA) III (DNA directed) polypeptide C antibody, polr3c.S antibody, POLR3C antibody, polr3c antibody, Polr3c antibody
    Background
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
    Molecular Weight
    60612
    Gene ID
    10623
    NCBI Accession
    NP_006459
    UniProt
    Q9BUI4
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