RNF144B antibody (AA 90-118)

Catalog No. ABIN1538681

Product Details anti-RNF144B Antibody

Target: RNF144B (Ring Finger Protein 144B (RNF144B))

Binding Specificity: AA 90-118

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF144B antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RNF144B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-118 amino acids from the Central region of human RNF144B.

Clone: RB37984

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: RNF144B Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Expiry Date: 6 months

Target Details for RNF144B

Target: RNF144B (Ring Finger Protein 144B (RNF144B))

Alternative Name: RNF144B (RNF144B Products)

Synonyms: IBRDC2 antibody, PIR2 antibody, bA528A10.3 antibody, p53RFP antibody, BC025007 antibody, E130105P19Rik antibody, Ibrdc2 antibody, Pir2 antibody, ring finger protein 144B antibody, RNF144B antibody, Rnf144b antibody

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a TP53/p53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death, But, it is not an anti-apoptotic protein per se.

Molecular Weight: 33697

Gene ID: 255488

NCBI Accession: NP_877434

UniProt: Q7Z419