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CLCF1 antibody (N-Term)

CLCF1 Reactivity: Human WB Host: Rabbit Polyclonal RB38733 unconjugated
Catalog No. ABIN1539397
  • Target See all CLCF1 Antibodies
    CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))
    Binding Specificity
    • 7
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 46-72, N-Term
    Reactivity
    • 34
    • 4
    • 2
    Human
    Host
    • 33
    • 5
    Rabbit
    Clonality
    • 35
    • 3
    Polyclonal
    Conjugate
    • 18
    • 6
    • 4
    • 3
    • 3
    • 3
    • 1
    This CLCF1 antibody is un-conjugated
    Application
    • 26
    • 18
    • 13
    • 7
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    Western Blotting (WB)
    Predicted Reactivity
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CLCF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of human CLCF1.
    Clone
    RB38733
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CLCF1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    CLCF1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.
    Expiry Date
    6 months
  • Target
    CLCF1 (Cardiotrophin-Like Cytokine Factor 1 (CLCF1))
    Alternative Name
    CLCF1 (CLCF1 Products)
    Synonyms
    clc antibody, nr6 antibody, bsf3 antibody, nnt1 antibody, ciss2 antibody, CLCF1 antibody, BSF-3 antibody, BSF3 antibody, CISS2 antibody, CLC antibody, NNT-1 antibody, NNT1 antibody, NR6 antibody, Bsf3 antibody, Clc antibody, cardiotrophin like cytokine factor 1 antibody, cardiotrophin-like cytokine factor 1 antibody, clcf1 antibody, CLCF1 antibody, Clcf1 antibody
    Background
    This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Molecular Weight
    25176
    Gene ID
    23529
    NCBI Accession
    NP_001159684, NP_037378
    UniProt
    Q9UBD9
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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