SAV1 antibody (C-Term)
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- Target See all SAV1 Antibodies
- SAV1 (Salvador Homolog 1 (SAV1))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SAV1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- PCAPSVPRYD QPPPITYQPQ QTERNQSLLV PANPYHTAEI PDWLQVYARA
- Predicted Reactivity
- Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against Sav1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Sav1
- Top Product
- Discover our top product SAV1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 386 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SAV1 (Salvador Homolog 1 (SAV1))
- Alternative Name
- Sav1 (SAV1 Products)
- Synonyms
- SAV antibody, WW45 antibody, WWP4 antibody, 1700040G09Rik antibody, Salv antibody, Sav antibody, Wwp3 antibody, Wwp4 antibody, salvador family WW domain containing protein 1 antibody, salvador family WW domain containing 1 antibody, SAV1 antibody, Sav1 antibody
- Background
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Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Alias Symbols: 1700040G09Rik, Sav, WW45, Wwp3, Wwp4
Protein Size: 386 - Molecular Weight
- 42 kDa
- Gene ID
- 64010
- NCBI Accession
- NM_022028, NP_071311
- UniProt
- Q8VEB2
- Pathways
- Stem Cell Maintenance
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