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SAV1 antibody (C-Term)

SAV1 Reactivity: Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1544254
  • Target See all SAV1 Antibodies
    SAV1 (Salvador Homolog 1 (SAV1))
    Binding Specificity
    • 8
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 31
    • 7
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Horse, Pig, Rabbit, Cow
    Host
    • 25
    • 6
    • 1
    Rabbit
    Clonality
    • 29
    • 3
    Polyclonal
    Conjugate
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    This SAV1 antibody is un-conjugated
    Application
    • 29
    • 19
    • 7
    • 5
    • 4
    • 2
    Western Blotting (WB)
    Sequence
    PCAPSVPRYD QPPPITYQPQ QTERNQSLLV PANPYHTAEI PDWLQVYARA
    Predicted Reactivity
    Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against Sav1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the C-terminal region of Sav1
    Top Product
    Discover our top product SAV1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 386 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Target
    SAV1 (Salvador Homolog 1 (SAV1))
    Alternative Name
    Sav1 (SAV1 Products)
    Synonyms
    SAV antibody, WW45 antibody, WWP4 antibody, 1700040G09Rik antibody, Salv antibody, Sav antibody, Wwp3 antibody, Wwp4 antibody, salvador family WW domain containing protein 1 antibody, salvador family WW domain containing 1 antibody, SAV1 antibody, Sav1 antibody
    Background
    Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
    Alias Symbols: 1700040G09Rik, Sav, WW45, Wwp3, Wwp4
    Protein Size: 386
    Molecular Weight
    42 kDa
    Gene ID
    64010
    NCBI Accession
    NM_022028, NP_071311
    UniProt
    Q8VEB2
    Pathways
    Stem Cell Maintenance
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