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anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody

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Image for anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody
Antigen: Nuclease-sensitive element-binding protein 1 (YBX1)
Clonality: Polyclonal
Application: Western Blotting (WB), Immunohistochemistry (IHC)
Reactivity: Human
Host: Rabbit
3 references available 3 references available
Quantity: 100ug (200ug/ml) (Product variants)
Price: 301,50 $   (Plus shipping costs and VAT, Invoice in EUR)
Order number: ABIN155053
Availability: Ships within 1 Business day
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Additional Information  » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody

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Antigen Nuclease-sensitive element-binding protein 1 (YBX1)
Gene ID 4904
Reactivity Human
Clonality Polyclonal
Format Affinitiy-purified
Isotype IgG »Matching secondary antibodies
Description Members of Y-box binding protein family all contain a DNA binding domain, called the cold shock domain, comprising of 80 amino acids, which is highly conserved from prokaryotes to eukaryotes. Y-box binding protein-1 (YB-1) is a prototypic member of this family and was originally isolated as a DNA binding protein recognizing the Y-box sequence within the MHC class II gene promoter region. This box is found in the promoter region of several genes involved in positive regulation of cell cycle, such as proliferating cell nuclear antigen, DNA topoisomerase IIa, DNA-polymerase-alpha and cyclins. Consequently, YB-1 is thought to play crucial roles for cell proliferation and carcinogenesis. YB-1 has been reported to be a prognostic marker of breast cancer, ovarian cancer, lung cancer, thyroid cancer, and synovial sarcoma. These findings indicate the significance of YB-1 for the progression of malignant diseases. Alternative names: BP-8, CSDA2, CSDB, DBPB, MDR-NF1, MGC104858, MGC110976, MGC117250, NSEP-1, NSEP1, YB-1, YB1, YBX1, DNA-binding protein B, Y box-binding protein I, nuclease sensitive element binding protein 1.
Host Rabbit

Application Details  » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody

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Application Western Blotting (WB), Immunohistochemistry (IHC)
» Click here to view 3 available protocols!
Application Notes WB: 1:1000. IHC (p): 1:50 to 1:200 depending on type of tissue
Concentration 200ug/ml
Storage Store aliquots at -20 C. Avoid repeated thawing and freezing
Research Area Cancer
Restrictions For Research Use only

Publications  » anti-nuclease-sensitive element-binding protein 1 (YBX1) (N-Term) antibody

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Publications Krohn R, Raffetseder U, Bot I et al.: "Y-Box Binding Protein-1 Controls CC Chemokine Ligand-5 (CCL5) Expression in Smooth Muscle Cells and Contributes to Neointima Formation in Atherosclerosis-Prone Mice" In: Circulation , Vol. Epub ahead of print, 2007 (PubMed)

Frye, Halfter, Djudjaj et al.: "Y-box protein-1 is actively secreted through a non-classical pathway and acts as an extracellular mitogen." In: EMBO reports , Vol. 10, Issue 7, pp. 783-9, 2009 (PubMed)

Rauen, Raffetseder, Frye et al.: "YB-1 acts as ligand for Notch-3 receptors and modulates receptor activation." In: The Journal of biological chemistry , 2009 (PubMed)

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