Prothrombin antibody (Coagulation Factor II (thrombin)) (N-Term)

Details for Product anti-F2 Antibody No. ABIN1583288, Supplier: Log in to see
Antigen
  • zgc:66319
  • wu:fb57c10
  • wu:fd42e09
  • wu:fd59d01
  • Cf-2
  • Cf2
  • FII
  • thrombin
  • PT
  • RPRGL2
  • THPH1
  • prothrombin
  • AA959438
  • AI255193
  • AI327365
  • C1sa
  • HTRA
  • HTRA1
  • F2
  • coagulation factor II (thrombin)
  • cell division cycle 34
  • chymase 1, mast cell
  • coagulation factor II
  • complement component 1, s subcomponent
  • HtrA serine peptidase 1
  • HtrA serine peptidase 2
  • melanoma antigen family B, 17-like
  • prothrombin-like
  • serine protease
  • THROMBIN protein
  • f2
  • F2
  • Cdc34
  • CMA1
  • C1s
  • Htra1
  • HTRA2
  • LOC783975
  • LOC100856539
  • HTRA
  • THROMBIN
Alternatives
anti-Human Prothrombin antibody for Blocking Antibody
Epitope
N-Term
8
8
6
6
5
4
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
137
64
36
8
7
3
2
2
2
2
1
Host
Rabbit
71
63
56
8
4
2
1
Clonality
Polyclonal
Conjugate
This Prothrombin antibody is un-conjugated
22
12
9
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
140
107
29
16
14
14
12
11
11
8
6
6
3
3
2
1
1
1
1
1
1
1
Options
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Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human prothrombin DCP.
Purification Antibody was purified by Protein-A affinity chromatography.
Alternative Name Prothrombin (F2 Antibody Abstract)
Background Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions. Factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Thrombin functions in blood homeostasis, inflammation and wound healing. Defects in thrombin are the cause of factor II deficiency (FA2D), a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Genetic variations in thrombin are linked to ischemic stroke and to thrombosis (THR), a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation.
UniProt P00734
Research Area Cardiovascular, Coagulation
Pathways Complement System, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling
Application Notes ELISA: 1:500-1:1.000, WB: 1:100-1:500, IHC: 1:100-1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 1 mg/ml BSA, 25% glycerol with 0.09% sodium azide.
Preservative Sodium azide
Precaution of Use Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Handling Advice Minimize freeze-thaw cycles.
Storage -20°C
Expiry Date 12 months
Supplier Images
Immunohistochemistry (IHC) image for anti-Prothrombin antibody (Coagulation Factor II (thrombin)) (N-Term) (ABIN1583288) anti-Coagulation Factor II (thrombin) (F2) (N-Term) antibody
Product cited in: Fritze, Zhang, Li, Chai, Mulholland: "Thrombin mediates vagal apoptosis and dysfunction in inflammatory bowel disease." in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, Vol. 18, Issue 8, pp. 1495-506, 2014 (PubMed).