BIRC5 antibody (Baculoviral IAP Repeat-Containing 5) (Middle Region)

Details for Product anti-BIRC5 Antibody No. ABIN1583512, Supplier: Log in to see
Antigen
  • API4
  • EPR-1
  • AAC-11
  • Api4
  • TIAP
  • survivin40
  • AP14
  • baculoviral IAP repeat containing 5
  • baculoviral IAP repeat-containing 5-like
  • baculoviral IAP repeat-containing 5
  • BIRC5
  • LOC696283
  • Birc5
Alternatives
anti-Human BIRC5 antibody for Immunofluorescence (fixed cells)
Epitope
Middle Region
20
10
5
4
3
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Dog (Canine), Cow (Bovine), Pig (Porcine)
69
31
9
Host
Rabbit
53
27
4
Clonality
Polyclonal
Conjugate
This BIRC5 antibody is un-conjugated
3
2
2
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
60
24
21
13
13
12
5
3
2
2
2
1
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen KLH-conjugated synthetic peptide encompassing a sequence within the middle region of human BIRC5.
Cross-Reactivity Dog (Canine), Cow (Bovine), Pig (Porcine)
Purification Antibody was purified by Protein-G affinity chromatography.
Alternative Name BIRC5 (BIRC5 Antibody Abstract)
Background BIRC5 (Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor suvivin) is a component of the chromosomal passenger complex (CPC), a key regulator of mitosis that functions at the centromere to ensure correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. With RAN, survivin forms a scaffold for mitotic spindle formation to deliver the RAN effector TPX2 to microtubules. Survivin plsys a role in neoplasia. It inhibits caspase-3 and caspase-7, blocking a default induction of apoptosis in G2/M phase. It is expressed in fetal kidney, liver, lung, brain, adenocarcinomas, lymphomas, renal cell carcinoma cell lines.
UniProt O15392
Pathways Apoptosis, Cell Division Cycle
Application Notes ELISA: 1:500-1:1.000, WB: 1:100-1:500, IHC: 1:100-1:500
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer Each vial contains 0.1 mg IgG in 0.1 mL of PBS pH7.4 with 0.09% sodium azide.
Preservative Sodium azide
Precaution of Use Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Handling Advice Minimize freeze-thaw cycles.
Storage -20°C
Expiry Date 12 months