BCL3 antibody

Catalog No. ABIN161379

Product Details anti-BCL3 Antibody

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Reactivity: Hamster

Host: Hamster

Clonality: Monoclonal

Conjugate: This BCL3 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Mouse Bcl-3

Purification: Purified

Immunogen: recombinant Bcl-3-6-histidine tag . Fusion Partner: SP2/0 myeloma . Donor: Armenian Hamster

Clone: Ham 150-3-5

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/ml

Storage: 4 °C

Target Details for BCL3

Target: BCL3 (B-Cell CLL/lymphoma 3 (BCL3))

Alternative Name: Bcl-3 (BCL3 Products)

Synonyms: BCL3 antibody, AI528691 antibody, Bcl-3 antibody, BCL4 antibody, D19S37 antibody, B-cell CLL/lymphoma 3 antibody, B cell leukemia/lymphoma 3 antibody, BCL3 antibody, Bcl3 antibody

Background: Anti-mouse Bcl-3 monoclonal antibody reacts with both mouse and human Bcl-3 B-cell Leukemia/lymphoma 3). The proto-oncoprotein Bcl-3 is a member of the IkappaB family and is present predominantly in the nucleus. This protein has been shown to function as a transcriptional co-activator for homodimers of NF-kappaB p50 and p50B. In addition to p50 and p52, Bcl-3 also associates with nuclear proteins Jab1, Pirin, Tip60 and Bard1. The mouse Bcl-3 coding region exhibits 80% homology with human Bcl-3 which is associated with human B-cell chronic lymphocytic leukemias (CLLs). Bcl-3 is detected in various tissues such as spleen and other lymphoid organs. Applications for this clone include Western blotting, ELISA and flow cytometry.

Pathways: NF-kappaB Signaling, Maintenance of Protein Location, Protein targeting to Nucleus