Crystallin, alpha A (CRYAA) antibody

Antigen: Crystallin, alpha A (CRYAA)

Synonyms: CRYA1, HSPB4, Crya1, lop18, Acry-1, Crya-1, DAcry-1, AI323437, cryaa-A, CRYAA, fc06h04, MGC92036, zgc:92036, wu:fc06h04, alpha-a-crystallin

Clonality: Monoclonal (C9F2)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN165393

Additional Information

Alternative name: alpha crystallin A

Immunogen: Recombinant human alpha-Crystallin A protein. Anti-human Crystallin (A mAb, clone c9F2, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human Crystallin alphaA.

Isotype: IgG1 kappa  (Matching secondary antibodies)

Clone: C9F2

Description: Alpha-crystallins, a major protein of the ocular lens, are thought to play a role in maintaining lens transparency, which are composed of two gene products alpha-A and alpha-B, for acidic and basic, respectively. alpha-crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP). They act as molecular chaperones and hold unfolded or misfolded proteins in large, water-soluble low molecular weight aggregates. These heterogeneous aggregates consist of 30-40 subunits of alpha-crystallins, and the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha-crystallins are an autokinase activity and the participation in the intracellular architecture.

Application Details

Application Notes: The antibody has been tested by ELISA and by Western blot analysis

Concentration: 1mg/ml

Purification: The antibody was purified from mouse ascitic fluid by protein-G affinity chromatography. Store at 4C for up to one month. Store at -20C for long term storage. Avoid repeated freezing and thawing.

Buffer: Liquid. Supplied in phosphate buffered saline, pH 7.4 with 0.1% Sodium Azide.

Restrictions: For Research Use only