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WDFY1 antibody (AA 21-120) (Alexa Fluor 350)

WDFY1 Reactivity: Rat FACS, IF (cc), IF (p) Host: Rabbit Polyclonal Alexa Fluor 350
Catalog No. ABIN1693986
  • Target See all WDFY1 Antibodies
    WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))
    Binding Specificity
    • 15
    • 6
    • 3
    • 1
    • 1
    AA 21-120
    Reactivity
    • 19
    • 17
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Rat
    Host
    • 31
    • 1
    Rabbit
    Clonality
    • 32
    Polyclonal
    Conjugate
    • 8
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This WDFY1 antibody is conjugated to Alexa Fluor 350
    Application
    • 13
    • 12
    • 12
    • 9
    • 6
    • 5
    • 3
    • 2
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse,Dog,Cow,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human WDFY1
    Isotype
    IgG
    Top Product
    Discover our top product WDFY1 Primary Antibody
  • Application Notes
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    WDFY1 (WD Repeat and FYVE Domain Containing 1 (WDFY1))
    Alternative Name
    WDFY1 + WDFY2 (WDFY1 Products)
    Synonyms
    FENS-1 antibody, WDF1 antibody, ZFYVE17 antibody, 1700013B03Rik antibody, 1700120F24Rik antibody, Jr1 antibody, mKIAA1435 antibody, MGC93914 antibody, zgc:101764 antibody, zgc:109909 antibody, WD repeat and FYVE domain containing 1 antibody, WDFY1 antibody, Wdfy1 antibody, wdfy1 antibody
    Background

    Synonyms: FENS 1, FENS-1, FENS1, KIAA1435, Phosphoinositide binding protein 1, Phosphoinositide binding protein SR1, Phosphoinositide-binding protein 1, WD repeat and FYVE domain containing 1, WD repeat and FYVE domain-containing protein 1, WD40 and FYVE domain containing protein 1, WD40- and FYVE domain-containing protein 1, WDF1, WDFY1, WDFY1_HUMAN, ZFYVE17, Zinc finger FYVE domain containing protein 17, Zinc finger FYVE domain-containing protein 17, WDFY2, WD repeat and FYVE domain-containing protein 2, Propeller-FYVE protein, WD40- and FYVE domain-containing protein 2, Zinc finger FYVE domain-containing protein 22, WDF2, ZFYVE22

    Background: WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDFY1 positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. WDFY1 Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines. WDFY2 acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. WDFY2 positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1

    Gene ID
    57590, 115825
    UniProt
    Q8IWB7, Q96P53
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