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Ficolin 2 antibody (AA 231-313) (Alexa Fluor 488)

FCN2 Reactivity: Human WB, IF (p), IF (cc) Host: Rabbit Polyclonal Alexa Fluor 488
Catalog No. ABIN1694832
  • Target See all Ficolin 2 (FCN2) Antibodies
    Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))
    Binding Specificity
    • 14
    • 3
    • 1
    • 1
    AA 231-313
    Reactivity
    • 27
    • 2
    • 1
    Human
    Host
    • 21
    • 7
    Rabbit
    Clonality
    • 22
    • 6
    Polyclonal
    Conjugate
    • 13
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Ficolin 2 antibody is conjugated to Alexa Fluor 488
    Application
    • 26
    • 12
    • 12
    • 8
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Cross-Reactivity
    Human
    Predicted Reactivity
    Mouse,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Ficolin 2/Ficolin B
    Isotype
    IgG
    Top Product
    Discover our top product FCN2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    Ficolin 2 (FCN2) (Ficolin (Collagen/fibrinogen Domain Containing Lectin) 2 (Hucolin) (FCN2))
    Alternative Name
    Ficolin 2/Ficolin B (FCN2 Products)
    Synonyms
    EBP-37 antibody, FCNL antibody, P35 antibody, ficolin-2 antibody, Fcn2 antibody, FCN1 antibody, fcn2 antibody, fcn2.S antibody, ficolin 2 antibody, ficolin B antibody, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) antibody, ficolin 2 L homeolog antibody, FCN2 antibody, Fcnb antibody, fcn2.L antibody
    Background

    Synonyms: 37 kDa elastin-binding protein, Collagen/fibrinogen domain containing protein 2, Collagen/fibrinogen domain-containing protein 2, EBP 37, EBP-37, EBP37, FCN 2, Fcn2, FCN2_HUMAN, FCNL, Ficolin collagen/fibrinogen domain containing lectin 2 hucolin, Ficolin B, Ficolin beta, Ficolin-2, Ficolin-B, Ficolin-beta, Ficolin2, Hucolin, L ficolin, L-ficolin, OTTHUMP00000022518, P35, RP11 263F14.2, Serum lectin p35.

    Background: Ficolin B is the designation in mouse and rat of a protein also known as L-ficolin, ficolin-2, collagen/fibrinogen domain-containing protein 2, serum lectin p35, EBP-37 or hucolin. Ficolin B is a 313 amino acid member of the ficolin lectin family. It is a secreted innate immunity pattern recognition molecule expressed in liver and plasma that forms a disulfide-linked homopolymer. This extensive N-terminal disulfide bridge formation can lead to a functional dodecamer polypeptide. Ficolin B binds to DNA ligands expressed by late apoptotic and necrotic cells to increase attachment and engulfment. Variation in ficolin B concentrations amongst individuals is associated with polymorphisms in the promoter and structural portion of the FCN2 gene. In patients with Beht's disease (BD), there exists a significant difference in allele frequency for FCN2 gene single nucleotide polymorphisms (SNPs) within the -557 and -64 promoter sites within HLA-B51 positive and HLA-B51 negative subgroups.

    Gene ID
    2220
    Pathways
    Complement System
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