FN3K antibody (AA 201-309) (Alexa Fluor 488)

Catalog No. ABIN1694833

Product Details anti-FN3K Antibody (Alexa Fluor 488)

Target: FN3K (Fructosamine 3 Kinase (FN3K))

Binding Specificity: AA 201-309

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FN3K antibody is conjugated to Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FN3K

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FN3K

Target: FN3K (Fructosamine 3 Kinase (FN3K))

Alternative Name: FN3K (FN3K Products)

Synonyms: Afu1g07040 antibody, An07g09600 antibody, AO090012000956 antibody, 2310074G21Rik antibody, Fnsk antibody, fructosamine-3-kinase antibody, Fructosamine-3-kinase antibody, fructosamine 3 kinase antibody, AFUA_1G07040 antibody, ANI_1_1220064 antibody, GL50803_2969 antibody, AOR_1_1682194 antibody, BDBG_05694 antibody, VDBG_05566 antibody, BBMN68_411 antibody, Tsp_00557 antibody, Fn3k antibody, FN3K antibody

Background:

Synonyms: 2310074G21Rik, Fnsk, Fructosamine 3 kinase, RP23-293H17.4, FN3K_HUMAN.

Background: Amines, including those present on proteins, spontaneously react with glucose to make fructosamines in a reaction termed glycation. Fructosamine 3-kinase (FN3K), a 309-amino acid enzyme initially identified in erythrocytes, catalyzes the ATP-dependent phosphorylation of the third carbon on both D- and L-fructosamines, leading to their destabilization and eventually, their removal from the protein. FN3K is a monomer that is ubiquitously expressed in mammalian tissue and phosphorylates both low molecular mass and protein-bound fructosamines which are formed as a result of glycation of glucose with primary amines. FN3K protects proteins from the harmful effects of nonenzymatic glycation, and may also be involved in peptide repair and cell metabolism. FN3KRP (fructosamine-3-kinase-related protein) is a 309 amino acid protein that is expressed in erythrocytes, bone marrow, spleen, brain and kidney and belongs to the fructosamine kinase family. FN3KRP functions to phosphorylate psicoamines and ribulosamines on the third carbon of their sugar moiety, thereby leading to the deglycation of the target amines.

Gene ID: 64122