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DOCK4 antibody (AA 1001-1100) (Alexa Fluor 488)

DOCK4 Reactivity: Human IF (p), IF (cc) Host: Rabbit Polyclonal Alexa Fluor 488
Catalog No. ABIN1695194
  • Target See all DOCK4 Antibodies
    DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))
    Binding Specificity
    • 14
    • 3
    • 3
    • 2
    • 1
    • 1
    AA 1001-1100
    Reactivity
    • 33
    • 11
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 30
    • 4
    Rabbit
    Clonality
    • 31
    • 3
    Polyclonal
    Conjugate
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DOCK4 antibody is conjugated to Alexa Fluor 488
    Application
    • 13
    • 12
    • 9
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DOCK4
    Isotype
    IgG
    Top Product
    Discover our top product DOCK4 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))
    Alternative Name
    DOCK4 (DOCK4 Products)
    Synonyms
    DOCK4 antibody, 5330406C03 antibody, 6330411N01Rik antibody, AF263288 antibody, C030023J22 antibody, mKIAA0716 antibody, dedicator of cytokinesis 4 antibody, DOCK4 antibody, NAEGRDRAFT_81257 antibody, Dock4 antibody
    Background

    Synonyms: Dedicator of cytokinesis protein 4, Dock4, DOCK4_HUMAN, KIAA0716.

    Background: DOCK 4 is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.

    Gene ID
    9732
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