GNL2 antibody (AA 1-100) (Alexa Fluor 488)

Catalog No. ABIN1695870

Product Details anti-GNL2 Antibody (Alexa Fluor 488)

Target: GNL2 (Guanine Nucleotide Binding Protein Like Protein 2 (GNL2))

Binding Specificity: AA 1-100

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNL2 antibody is conjugated to Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GNL2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GNL2

Target: GNL2 (Guanine Nucleotide Binding Protein Like Protein 2 (GNL2))

Alternative Name: GNL2 (GNL2 Products)

Synonyms: HUMAUANTIG antibody, NGP1 antibody, Ngp-1 antibody, BC003262 antibody, RGD1305006 antibody, G protein nucleolar 2 antibody, guanine nucleotide binding protein-like 2 (nucleolar) antibody, GNL2 antibody, Gnl2 antibody

Background:

Synonyms: Autoantigen NGP-1, Autoantigen NGP1, DJ423B22.6 novel nucleolar guanosine 5'-triphosphate binding protein, FLJ40906, GNL2, Guanine nucleotide binding protein-like 2 nucleolar, HUMAUANTIG, NGP1, NOG2_HUMAN, Nucleolar GTP binding protein 2, Nucleolar GTP-binding protein 2, Nucleolar GTPase.

Background: GNL2 is a nucleolar guanasine-triphosphate binding protein that is ubiquitously expressed at low levels in almost all tissues. GNL2 is involved in the crucial process of trafficking proteins out of the nucleus. Specifically, it is a GTPase that interacts with the 60s preribosomal subunit in the nucleus and facilitates export of the subunit into the cytoplasm. GTPases are responsible for the hydrolysis of GTP by way of a protein region dubbed the G domain. GTPases are often involved in the translocating proteins through membranes gleaning energy for the activity by hydrolizing GTP. GNL2 shares G domain homology and some functionality with nucleostemin (GNL3), another nuclear GTPase. Highest expression of GNL2 is found in testis.

Gene ID: 29889