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GMEB2 antibody (AA 101-200) (Cy3)

GMEB2 Reactivity: Mouse WB, IF (cc), IF (p) Host: Rabbit Polyclonal Cy3
Catalog No. ABIN1702368
  • Target See all GMEB2 Antibodies
    GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
    Binding Specificity
    • 14
    • 2
    • 1
    • 1
    AA 101-200
    Reactivity
    • 25
    • 15
    • 11
    • 2
    • 2
    • 2
    • 2
    • 1
    Mouse
    Host
    • 29
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GMEB2 antibody is conjugated to Cy3
    Application
    • 20
    • 12
    • 12
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Cross-Reactivity
    Mouse
    Predicted Reactivity
    Human,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GMEB2
    Isotype
    IgG
    Top Product
    Discover our top product GMEB2 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
    Alternative Name
    GMEB2 (GMEB2 Products)
    Synonyms
    GMEB2 antibody, P79PIF antibody, PIF79 antibody, AI839884 antibody, glucocorticoid modulatory element binding protein 2 antibody, glucocorticoid modulatory element binding protein 2 S homeolog antibody, GMEB2 antibody, gmeb2.S antibody, Gmeb2 antibody
    Background

    Synonyms: GMEB2, DNA binding protein p79P, DNA-binding protein p79P, Glucocorticoid modulatory element binding protein 2, Glucocorticoid modulatory element-binding protein 2, GMEB 2, GMEB-2, Gmeb2, GMEB2_HUMAN, KIAA1269, P79P, Parvovirus initiation factor p79, P p79, P79, RP4 663D7.1.

    Background: GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.

    Gene ID
    26205
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