PHC1 antibody (AA 751-900) (HRP)

Catalog No. ABIN1712250

Product Details anti-PHC1 Antibody (HRP)

Target: PHC1 (Polyhomeotic-Like 1 (PHC1))

Binding Specificity: AA 751-900

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHC1 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EDR1/PHC1

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PHC1

Target: PHC1 (Polyhomeotic-Like 1 (PHC1))

Alternative Name: EDR1/PHC1 (PHC1 Products)

Synonyms: EDR1 antibody, HPH1 antibody, RAE28 antibody, AW557034 antibody, Edr antibody, Edr1 antibody, Mph1 antibody, Rae-28 antibody, rae28 antibody, polyhomeotic homolog 1 antibody, polyhomeotic-like 1 (Drosophila) antibody, Phc1 antibody, PHC1 antibody

Background:

Synonyms: Early development regulatory protein 1, EDR1 PH1, hPH1, mPH1, PH1, Polyhomeotic-like protein 1, Rae28, PHC1_HUMAN.

Background: PHC1 is a 1,004 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex. Specifically, the PcG PRC1 complex modifies histones, remodels chromatin and mediates monoubiquination of Histone H2A. Other constituent proteins involved in the PcG PRC1 complex are Mel-18, Bmi-1, M33, MPc2, MPc3, RING1, Ring1b, as well as several others. Existing as a homodimer, PHC1 contains one FCS-type zinc finger and a SAM (sterile alpha motif) domain. PHC1 is encoded by a gene located on human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5 % of the human genome.

Gene ID: 1911