Calcineurin B antibody (pTyr106) (HRP)

Catalog No. ABIN1712443

Product Details anti-Calcineurin B Antibody (HRP)

Target: Calcineurin B (CAN)

Binding Specificity: pTyr106

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Calcineurin B antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Zebrafish (Danio rerio)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Guinea Pig,Drosophila

Purification: Purified by Protein A.

Immunogen: KLH conjugated syntheticphosphopeptide derived from human Calcineurin B around the phosphorylation site of Tyr106

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Calcineurin B

Target: Calcineurin B (CAN)

Alternative Name: Calcineurin B (CAN Products)

Synonyms: PPP3RL antibody, BcDNA:RH11383 antibody, CG4209 antibody, CNB antibody, Can antibody, CnB antibody, Dmel\\CG4209 antibody, canB-4F antibody, dCnB1 antibody, Cnb antibody, Cblp antibody, CaNB2 antibody, protein phosphatase 3 regulatory subunit B, beta antibody, Calcineurin B antibody, calcineurin B antibody, protein phosphatase 3, regulatory subunit B, beta antibody, protein phosphatase 3 regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) antibody, PPP3R2 antibody, CanB antibody, Cnb antibody, Ppp3r2 antibody, PPP3R1 antibody

Background:

Synonyms: Calcineurin B phospho Y106, Calcineurin B phospho Tyr106, p-Calcineurin B Tyr106, Calcineurin subunit B type 1, CALNB1, CANB1_HUMAN, Cna2, CNB, CNB1, OTTHUMP00000201960, OTTHUMP00000201961, Ppp3r1, PPP3R1 protein phosphatase 3 formerly 2B, regulatory subunit B, alpha isoform, alpha isoform calcineurin B, type I, calcineurin B, type I 19 kDa, protein phosphatase3 formerly2B, regulatory subunit B, alpha isoform antibody Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 2B regulatory subunit B alpha, protein phosphatase 3 formerly 2B, regulatory subunit B, 19 kDa, alpha isoform calcineurin B, type I, Protein phosphatase 3 regulatory subunit B alpha, Protein phosphatase 3 regulatory subunit B alpha isoform 1.

Background: In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. The PP2B family comprises subfamily members PP2B-A alpha, PP2B-A Beta and PP2B-A Gamma. Two additional regulatory subunits been identified, designated PP2B-B1 and PP2B-B2.

Gene ID: 5534

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling