AGPS antibody (AA 31-130) (HRP)

Catalog No. ABIN1712481

Product Details anti-AGPS Antibody (HRP)

Target: AGPS (Alkylglycerone Phosphate Synthase (AGPS))

Binding Specificity: AA 31-130

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGPS antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human AGPS/Alkyl-DHAP synthase

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for AGPS

Target: AGPS (Alkylglycerone Phosphate Synthase (AGPS))

Alternative Name: AGPS/Alkyl-DHAP synthase (AGPS Products)

Background:

Synonyms: AAG5, ADAP-S, ADAS, ADAS_HUMAN, ADHAPS, ADPS, Aging associated gene 5 protein, Aging-associated gene 5 protein, AGPS, ALDHPSY, Alkyl-DHAP synthase, Alkyldihydroxyacetonephosphate synthase, Alkyldihydroxyacetonephosphate synthase, peroxisomal, Alkylglycerone phosphate synthase, Alkylglycerone-phosphate synthase, peroxisomal.

Background: AGPS is a 658 amino acid enzyme that is required for glycerolipid metabolism and ether lipid biosynthesis. Localized to the inner aspect of the peroxisomal membrane, AGPS is likely part of a heterotrimeric complex that is also composed of GNPAT and a modified form of GNPAT. Containing one FAD-binding PCMH-type domain, AGPS utilizes FAD as a cofactor in the synthesis of alkyl-glycerone 3-phophate and a long-chain acid anion from 1-acteyl-glyerone 3-phosphate and a long-chain alcohol. Defects in the gene encoding AGPS results in rhizomelic chondrodysplasia punctata type 3, a disease characterized by vertebral disorders, severe mental retardation, cutaneous lesions, cataracts and rhizomelic shortening of the humerus and femur.

Gene ID: 8540

Pathways: SARS-CoV-2 Protein Interactome