ABCG5 antibody (AA 306-367)

Catalog No. ABIN1724807

Product Details anti-ABCG5 Antibody

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Binding Specificity: AA 306-367

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABCG5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Purification: Purified

Immunogen: Purified recombinant fragment of human ABCG5 (AA: 306-367) expressed in E. Coli.

Clone: 1B5D8

Isotype: IgG1

Application Details

Application Notes: Recommended Dilution:
ELISA: 1/10000
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C or at -20 °C for long term.

References for anti-ABCG5 antibody (ABIN1724807)

Li, Yin, Wei, Yan, Aung, Wu, Wu, Lin, Liu, Pan: "ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels." in: PLoS ONE, Vol. 7, Issue 5, pp. e37972, (2012) (PubMed).

Jakulj, Vissers, Tanck, Hutten, Stellaard, Kastelein, Dallinga-Thie: "ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis." in: Journal of lipid research, Vol. 51, Issue 10, pp. 3016-23, (2010) (PubMed).

Target Details for ABCG5

Target: ABCG5 (ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5))

Alternative Name: ABCG5 (ABCG5 Products)

Synonyms: DDBDRAFT_0205617 antibody, DDBDRAFT_0215344 antibody, DDB_0205617 antibody, DDB_0215344 antibody, STSL antibody, AW112016 antibody, cmp antibody, sterolin-1 antibody, trac antibody, ATP binding cassette subfamily G member 5 antibody, ATP-binding cassette, sub-family G (WHITE), member 5 antibody, ABC transporter G family protein antibody, ABCG5 antibody, abcg5 antibody, abcG5 antibody, Abcg5 antibody

Background: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.

Molecular Weight: 72.5 kDa

Gene ID: 64240

HGNC: 64240

Pathways: Lipid Metabolism