FGF4 antibody (AA 62-123)

Catalog No. ABIN1724834

Product Details anti-FGF4 Antibody

Target: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Binding Specificity: AA 62-123

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGF4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: purified

Immunogen: Purified recombinant fragment of humanFGF4 (AA: 62-123) expressed in E. coli.

Clone: 3A12G9

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

References for anti-FGF4 antibody (ABIN1724834)

Johannesson, Ståhlberg, Ameri, Sand, Norrman, Semb: "FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner." in: PLoS ONE, Vol. 4, Issue 3, pp. e4794, (2009) (PubMed).

Mayshar, Rom, Chumakov, Kronman, Yayon, Benvenisty: "Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal." in: Stem cells (Dayton, Ohio), Vol. 26, Issue 3, pp. 767-74, (2008) (PubMed).

Target Details for FGF4

Target: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Alternative Name: FGF4 (FGF4 Products)

Synonyms: HBGF-4 antibody, HST antibody, HST-1 antibody, HSTF1 antibody, K-FGF antibody, KFGF antibody, Fgf-4 antibody, Fgfk antibody, Hst1 antibody, Hstf-1 antibody, KS3 antibody, hst antibody, hst-1 antibody, kFGF antibody, Hst antibody, fibroblast growth factor 4 antibody, FGF4 antibody, Fgf4 antibody

Background:

Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

Aliases: HST, KFGF, HST-1, HSTF1, K-FGF, HBGF-5

Molecular Weight: 22 kDa

Gene ID: 2249

HGNC: 2249

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance