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CD74 antibody (AA 1-106)

CD74 Reactivity: Human WB, FACS, ELISA, ICC Host: Mouse Monoclonal 2D1B3 unconjugated
Catalog No. ABIN1724871
  • Target See all CD74 Antibodies
    CD74 (HLA-DR-gamma (CD74))
    Binding Specificity
    • 21
    • 16
    • 15
    • 11
    • 9
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-106
    Reactivity
    • 182
    • 64
    • 13
    • 11
    Human
    Host
    • 120
    • 80
    • 3
    • 2
    Mouse
    Clonality
    • 136
    • 67
    • 2
    Monoclonal
    Conjugate
    • 68
    • 17
    • 16
    • 10
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This CD74 antibody is un-conjugated
    Application
    • 125
    • 109
    • 79
    • 44
    • 37
    • 35
    • 29
    • 26
    • 18
    • 14
    • 13
    • 11
    • 9
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC)
    Purification
    purified
    Immunogen
    Purified recombinant fragment of human CD74 (AA: 1-106) expressed in E. coli.
    Clone
    2D1B3
    Isotype
    IgG1
  • Application Notes
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    4°C, -20°C for long term storage
  • Tian, Zhang, Li, Liu, Dong: "CD74: a potential novel target for triple-negative breast cancer." in: Tumour biology, Vol. 33, Issue 6, pp. 2273-7, (2012) (PubMed).

    Zheng, Yang, Rong, Yuan, Ma, Wang, Shen, Cui: "CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer." in: World journal of gastroenterology : WJG, Vol. 18, Issue 18, pp. 2253-61, (2012) (PubMed).

  • Target
    CD74 (HLA-DR-gamma (CD74))
    Alternative Name
    CD74 (CD74 Products)
    Synonyms
    DHLAG antibody, HLADG antibody, II antibody, Ia-GAMMA antibody, CLIP antibody, Ii antibody, INVG34 antibody, Iclp-1 antibody, iclp1 antibody, wu:fb11f09 antibody, wu:fb12a01 antibody, wu:fb13d06 antibody, wu:fk94e07 antibody, Iclp-2 antibody, cd74 antibody, iclp2 antibody, zgc:123161 antibody, CD74 molecule antibody, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antibody, CD74 molecule, major histocompatibility complex, class II invariant chain a antibody, CD74 molecule, major histocompatibility complex, class II invariant chain b antibody, CD74 antibody, Cd74 antibody, cd74a antibody, cd74b antibody
    Background

    Description: The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. ,

    Aliases: II, DHLAG, HLADG, Ia-GAMMA

    Molecular Weight
    33.5 kDa
    Gene ID
    972
    HGNC
    972
    Pathways
    Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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