TNFRSF10B antibody (AA 388-407)

Catalog No. ABIN1733770

Product Details anti-TNFRSF10B Antibody

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Binding Specificity: AA 388-407

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFRSF10B antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Specificity: Reacts with human and mouse DR5.

Purification: Purified

Immunogen: Synthetic peptide corresponding to aa 388- 407 of human DR5 precursor (accession no.AF012535)

Isotype: IgG

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
WB(2 μg/mL) ICC(5 μg/mL)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Target Details for TNFRSF10B

Target: TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))

Alternative Name: DR5 (TNFRSF10B Products)

Synonyms: TNFRSF10B antibody, dr5 antibody, cd262 antibody, killer antibody, trick2 antibody, trickb antibody, xDR-M1 antibody, xDR-M2 antibody, ztnfr9 antibody, trailr2 antibody, trick2a antibody, trick2b antibody, CD262 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, ZTNFR9 antibody, Ly98 antibody, MK antibody, tumor necrosis factor receptor superfamily, member 10b antibody, tumor necrosis factor receptor superfamily member 10b S homeolog antibody, tumor necrosis factor receptor superfamily member 10b L homeolog antibody, tumor necrosis factor receptor superfamily member 10b antibody, TNF receptor superfamily member 10b antibody, Tnfrsf10b antibody, TNFRSF10B antibody, tnfrsf10b.S antibody, tnfrsf10b.L antibody, tnfrsf10b antibody

Background: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain-containing receptors. TRAIL/Apo2L is a new member of the TNF family. A novel death domain containing receptor for TRAIL was recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several independent laboratories. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Tumor necrosis factor receptor superfamily member 10B Death receptor 5 TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2 CD_antigen: CD262 KILLER/DR5,TRICK2A, TRICK2B, TRICKB Gene name: TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9

Gene ID: 8795

UniProt: O14763

Pathways: p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity