CD38 antibody (Biotin)

Antigen: CD38

Synonyms: T10

Clonality: Monoclonal (HIT2)

Host: Mouse

Reactivity: Human

Conjugate: Biotin

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Catalog no.: ABIN179861

Additional Information

Isotype: IgG1, kappa chain

Clone: HIT2

Description: CD38 is a 45 kD type II transmembrane glycoprotein, also known as T10. It is an ADP-ribosyl hydrolase, expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscles, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, as well as adhesion and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38. Distribution: T, B, NK, myeloid, plasma, and dendritic cells Function: Ecto-ADP-ribosyl cyclase, calcium signaling, cell activation Synonyms: T10, ADP-ribosyl cyclase Structure: ADP-ribosyl cyclase, ectoenzyme, type II glycoprotein, 45 kD

Application Details

Application Notes: Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections. Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is < 1.0 µg per 10 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Purification: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.

Storage: The antibody solution should be stored undiluted at 4°C. Do not freeze.

Research Area: CD Antigens

Restrictions: For Research Use only

Images

anti-CD38 antibody (Biotin)